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Table 5 MDR analysis of gene–gene and gene–environment interactions in relation to LTBI and PTB

From: Screening toll-like receptor markers to predict latent tuberculosis infection and subsequent tuberculosis disease in a Chinese population

Best model Testing accuracy Testing sensitivity Testing OR Testing χ2 p Cross-validation consistency
PTB.vs.LTBI       
BCG 0.61 0.70 1.76(1.067-2.903)a 4.958 0.026a 6/10
rs10759932, rs7873784 0.76 0.72 3.29(2.096-8.283)a 9.253 0.0024a 10/10
rs10759932, rs7873784, rs10759931 0.84 0.81 5.67(3.158-14.99)a 12.67 0.0004a 10/10
LTBI.vs.HC       
rs5743836 0.56 0.55 1.68(1.189-2.365)a 8.76 0.0031a 9/10
rs3804100, rs1898830 0.69 0.63 4.57(1.532-13.61)a 7.88 0.005a 10/10
rs3804100, rs1898830, rs10759931 0.80 0.79 5.76(3.332-16.07)a 21.85 0.0001a 10/10
  1. PTB, pulmonary tuberculosis; LTBI, latent tuberculosis infection; HC, healthy control;MDR, multifactor dimensionality reduction.
  2. ap < 0.05.