Screening toll-like receptor markers to predict latent tuberculosis infection and subsequent tuberculosis disease in a Chinese population

Table 5 MDR analysis of gene–gene and gene–environment interactions in relation to LTBI and PTB

Best model	Testing accuracy	Testing sensitivity	Testing OR	Testing χ2	p	Cross-validation consistency
PTB.vs.LTBI
BCG	0.61	0.70	1.76(1.067-2.903)^a	4.958	0.026^a	6/10
rs10759932, rs7873784	0.76	0.72	3.29(2.096-8.283)^a	9.253	0.0024^a	10/10
rs10759932, rs7873784, rs10759931	0.84	0.81	5.67(3.158-14.99)^a	12.67	0.0004^a	10/10
LTBI.vs.HC
rs5743836	0.56	0.55	1.68(1.189-2.365)^a	8.76	0.0031^a	9/10
rs3804100, rs1898830	0.69	0.63	4.57(1.532-13.61)^a	7.88	0.005^a	10/10
rs3804100, rs1898830, rs10759931	0.80	0.79	5.76(3.332-16.07)^a	21.85	0.0001^a	10/10

PTB, pulmonary tuberculosis; LTBI, latent tuberculosis infection; HC, healthy control;MDR, multifactor dimensionality reduction.
^ap < 0.05.

ISSN: 1471-2350