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Table 4 Haplotypes of the TLR2 and TLR4 genes and their distributions in the three groups

From: Screening toll-like receptor markers to predict latent tuberculosis infection and subsequent tuberculosis disease in a Chinese population

SNP marker Haplotype Frequency (No., %) LTBI.vs.HC PTB.vs.LTBI
HC ( n  = 422) LTBI ( n  = 225) PTB ( n  = 109) P OR 95% CI P OR 95% CI
rs3804099 CC 183(21.7) 95(21.1) 52(23.8) 0.812 0.97 0.722-1.289 0.422 1.17 0.779-1.747
rs3804100 CT 185(21.9) 85(18.9) 36(16.5) 0.201 0.83 0.615-1.114 0.455 0.85 0.537-1.326
  TC 103(12.2) 56(12.4) 18(8.3) 0.900 1.02 0.709-1.465 0.106 0.63 0.341-1.129
  TT 373(44.2) 214(47.6) 112(51.4) 0.247 1.15 0.904-1.450 0.354 1.17 0.832-1.632
rs10759931 AT 376(44.4) 204(45.3) 136(62.4) 0.787 1.03 0.735-1.447 <0.001a 2.00 1.221-3.289
rs10759932 GT 218(25.7) 112(24.9) 22(10.1) 0.712 0.95 0.642-1.401 <0.001a 0.34 0.153-0.694
  GC 156(18.5) 88(19.6) 6(2.8) 0.639 1.07 0.693-1.646 <0.001a 0.12 0.022-0.379
  AC 94(11.4) 46(10.2) 54(24.7) 0.614 0.91 0.511-1.578 <0.001a 2.89 1.496-5.596
rs4986790 AC 644(76.3) 353(78.4) 157(72.0) 0.383 1.13 0.852-1.505 0.067 0.71 0.481-1.046
rs4986791 AT 49(5.8) 11(2.4) 18(8.3) 0.006 0.39 0.180-0.784 0.001a 3.59 1.570-8.565
  GC 33(3.9) 9(2.0) 0(0) 0.065 0.50 0.209-1.083 - - -
  GT 118(14.0) 77(17.1) 43(19.7) 0.134 1.27 0.915-1.755 0.409 1.19 0.766-1.833
  1. PTB, pulmonary tuberculosis; LTBI, latent tuberculosis infection; HC, healthy control.
  2. ap < 0.003125 (0.05/16), the difference was statistically significant after correction for multiple testing (Bonferroni correction).