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Table 3 Distribution of toll-like receptor alleles in the three groups

From: Screening toll-like receptor markers to predict latent tuberculosis infection and subsequent tuberculosis disease in a Chinese population

dbSNPS

 

Frequencies (No., %)

 

LTBI.vs.HC

TB.vs.LTBI

TB.vs.HC

Alleles

HC ( n  = 422)

LTBI ( n  = 225)

TB ( n  = 109)

p

OR

95% CI

p

OR

95% CI

p

OR

95% CI

TLR1_1805

G

74(8.7)

27(6.0)

12(5.5)

0.077

0.664

0.404-1.064

0.798

0.913

0.412-1.908

0.115

0.606

0.323-1.137

 

T

770(91.3)

423(94.0)

206(94.5)

0.077

1.506

0.940-2.473

0.798

1.095

0.524-2.425

0.115

1.650

0.880-3.095

rs3804099

C

282(33.4)

145(32.2)

54(24.8)

0.665

0.947

0.736-1.217

0.048

0.693

0.471-1.012

0.014

0.656

0.467-0.921

 

T

562(66.6)

305(67.8)

164(75.2)

0.665

1.055

0.859-1.244

0.048

1.443

0.988-2.124

0.014

1.524

1.086-2.139

rs5743708

A

840(99.5)

441(98.0)

212(96.8)

0.009

0.233

0.052-0.843

0.538

0.721

0.226-2.500

0.002

0.168

0.047-0.602a

 

G

4(0.5)

9(2.0)

6(3.2)

0.009

4.291

1.187-19.13

0.538

1.386

0.401-4.429

0.002

5.943

1.662-21.25a

rs3804100

C

252(29.9)

180(40.0)

86(39.4)

<0.001

1.566

1.223-2.003a

0.892

0.977

0.692-1.378

0.007

1.531

1.124-2.085

 

T

592(70.1)

270(60.0)

132(60.0)

<0.001

0.638

0.499-0.818a

0.892

1.023

0.742-1.387

0.007

0.653

0.480-0.890

rs1898830

A

480(56.9)

249(55.3)

120(55.0)

0.595

0.939

0.741-1/191

0.944

0.988

0.705-1.387

0.628

0.929

0.688-1.253

 

G

364(43.1)

201(44.7)

98(45.0)

0.595

1.064

0.840-1.349

0.944

1.012

0.721-1.419

0.628

1.077

0.798-1.453

rs4986790

A

767(90.9)

404(89.8)

185(84.9)

0.521

0.882

0.591-1.325

0.065

0.638

0.385-1.068

0.009

0.563

0.363-0.872

 

G

77(9.1)

46(10.2)

33(15.1)

0.521

1.133

0.754-1.691

0.065

1.567

0.937-2.595

0.009

1.777

1.146-2.754

rs4986791

C

760(90.0)

401(89.1)

180(82.6)

0.597

1.104

0.690-1.556

0.018

0.579

0.309-0.838a

0.002

0.524

0.345-0.794a

 

T

84(10.0)

49(10.9)

38(17.4)

0.597

0.905

0.642-1.449

0.018

1.727

1.193-3.235a

0.002

1.910

1.260-2.896a

rs11536889

C

235(27.8)

120(26.7)

60(72.5)

0.651

0.942

0.721-1.228

0.815

1.044

0.712-1.523

0.925

0.984

0.705-1.373

 

G

609(72.2)

330(73.3)

158(27.5)

0.651

1.061

0.814-1.386

0.815

0.958

0.657-1.404

0.925

1.016

0.728-1.418

rs10759932

C

252(29.9)

132(29.3)

59(27.1)

0.844

0.975

0.752-1.262

0.543

0.894

0.611-1.300

0.419

0.872

0.625-1.216

 

T

592(70.1)

318(70.7)

159(72.9)

0.844

1.026

0.792-1.330

0.543

1.119

0.769-1.637

0.419

1.147

0.822-1.601

rs7873784

C

193(22.9)

95(21.1)

32(14.7)

0.469

0.903

0.713-1.270

0.047

0.643

0.401-0.912

0.008

1.632

1.084-2.456

 

G

651(77.1)

355(78.9)

186(85.3)

0.469

1.107

0.787-1.403

0.047

1.555

1.017-2.494

0.008

0.613

0.407-0.923

rs10759931

A

501(59.4)

293(65.1)

142(65.1)

0.043

1.278

0.910-1.488

0.995

1.001

0.704-1.429

0.120

1.164

0.853-10589

 

G

343(40.6)

157(34.9)

76(34.9)

0.043

0.782

0.672-1.099

0.995

0.999

0.700-1.421

0.120

0.859

0.629-1.173

rs5743810

C

12(1.4)

8(1.8)

5(2.3)

0.621

1.255

0.441-3.366

0.710

1.238

0.330-4.557

0.361

1.628

0.567-4.670

 

T

832(98.6)

442(98.2)

213(97.7)

0.621

0.197

0.297-2.265

0.710

0.807

0.219-3.034

0.361

0.614

0.214-1.763

TLR_129

C

456(54.0)

258(57.3)

145(66.5)

0.255

1.143

0.774-1.251

0.023

1.478

0.674-1.335

0.001

0.932

0.689-1.261a

 

G

388(46.0)

192(42.7)

73(33.5)

0.255

0.875

0.799-1.292

0.023

0.676

0.749-1.484

0.001

1.073

0.793-1.451a

rs5743836

C

231(27.4)

151(35.6)

61(28.0)

0.020

1.340

1.038-1.728

0.147

0.769

0.530-1.111

0.857

1.031

0.740-1.437

 

T

613(72.6)

299(66.4)

157(72.0)

0.020

0.746

0.579-0.964

0.147

1.300

0.900-1.888

0.857

0.970

0.696-1.352

rs1870884

C

113(13.4)

58(12.9)

27(12.4)

0.800

0.957

0.669-1.359

0.855

0.955

0.563-1.591

0.696

0.914

0.584-1.433

 

T

731(86.6)

392(87.1)

191(87.6)

0.800

1.044

0.736-1.494

0.855

1.047

0.629-1.777

0.696

1.094

0.698-1.713

TIRAP_975

C

723(85.7)

367(81.6)

162(74.3)

0.053

0.740

0.539-1.019

0.031

0.654

0.438-0.983a

<0.001

0.484

0.338-0.694a

 

T

121(14.3)

83(18.4)

56(25.7)

0.053

1.351

0.981-1.855

0.031

1.535

1.017-2.286a

<0.001

2.066

1.442-2.960a

  1. PTB, pulmonary tuberculosis; LTBI, latent tuberculosis infection; HC, healthy control.
  2. ap < 0.003125 (0.05/16), the difference was statistically significant after correction for multiple testing (Bonferroni correction).