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Table 3 Distribution of toll-like receptor alleles in the three groups

From: Screening toll-like receptor markers to predict latent tuberculosis infection and subsequent tuberculosis disease in a Chinese population

dbSNPS   Frequencies (No., %)   LTBI.vs.HC TB.vs.LTBI TB.vs.HC
Alleles HC ( n  = 422) LTBI ( n  = 225) TB ( n  = 109) p OR 95% CI p OR 95% CI p OR 95% CI
TLR1_1805 G 74(8.7) 27(6.0) 12(5.5) 0.077 0.664 0.404-1.064 0.798 0.913 0.412-1.908 0.115 0.606 0.323-1.137
  T 770(91.3) 423(94.0) 206(94.5) 0.077 1.506 0.940-2.473 0.798 1.095 0.524-2.425 0.115 1.650 0.880-3.095
rs3804099 C 282(33.4) 145(32.2) 54(24.8) 0.665 0.947 0.736-1.217 0.048 0.693 0.471-1.012 0.014 0.656 0.467-0.921
  T 562(66.6) 305(67.8) 164(75.2) 0.665 1.055 0.859-1.244 0.048 1.443 0.988-2.124 0.014 1.524 1.086-2.139
rs5743708 A 840(99.5) 441(98.0) 212(96.8) 0.009 0.233 0.052-0.843 0.538 0.721 0.226-2.500 0.002 0.168 0.047-0.602a
  G 4(0.5) 9(2.0) 6(3.2) 0.009 4.291 1.187-19.13 0.538 1.386 0.401-4.429 0.002 5.943 1.662-21.25a
rs3804100 C 252(29.9) 180(40.0) 86(39.4) <0.001 1.566 1.223-2.003a 0.892 0.977 0.692-1.378 0.007 1.531 1.124-2.085
  T 592(70.1) 270(60.0) 132(60.0) <0.001 0.638 0.499-0.818a 0.892 1.023 0.742-1.387 0.007 0.653 0.480-0.890
rs1898830 A 480(56.9) 249(55.3) 120(55.0) 0.595 0.939 0.741-1/191 0.944 0.988 0.705-1.387 0.628 0.929 0.688-1.253
  G 364(43.1) 201(44.7) 98(45.0) 0.595 1.064 0.840-1.349 0.944 1.012 0.721-1.419 0.628 1.077 0.798-1.453
rs4986790 A 767(90.9) 404(89.8) 185(84.9) 0.521 0.882 0.591-1.325 0.065 0.638 0.385-1.068 0.009 0.563 0.363-0.872
  G 77(9.1) 46(10.2) 33(15.1) 0.521 1.133 0.754-1.691 0.065 1.567 0.937-2.595 0.009 1.777 1.146-2.754
rs4986791 C 760(90.0) 401(89.1) 180(82.6) 0.597 1.104 0.690-1.556 0.018 0.579 0.309-0.838a 0.002 0.524 0.345-0.794a
  T 84(10.0) 49(10.9) 38(17.4) 0.597 0.905 0.642-1.449 0.018 1.727 1.193-3.235a 0.002 1.910 1.260-2.896a
rs11536889 C 235(27.8) 120(26.7) 60(72.5) 0.651 0.942 0.721-1.228 0.815 1.044 0.712-1.523 0.925 0.984 0.705-1.373
  G 609(72.2) 330(73.3) 158(27.5) 0.651 1.061 0.814-1.386 0.815 0.958 0.657-1.404 0.925 1.016 0.728-1.418
rs10759932 C 252(29.9) 132(29.3) 59(27.1) 0.844 0.975 0.752-1.262 0.543 0.894 0.611-1.300 0.419 0.872 0.625-1.216
  T 592(70.1) 318(70.7) 159(72.9) 0.844 1.026 0.792-1.330 0.543 1.119 0.769-1.637 0.419 1.147 0.822-1.601
rs7873784 C 193(22.9) 95(21.1) 32(14.7) 0.469 0.903 0.713-1.270 0.047 0.643 0.401-0.912 0.008 1.632 1.084-2.456
  G 651(77.1) 355(78.9) 186(85.3) 0.469 1.107 0.787-1.403 0.047 1.555 1.017-2.494 0.008 0.613 0.407-0.923
rs10759931 A 501(59.4) 293(65.1) 142(65.1) 0.043 1.278 0.910-1.488 0.995 1.001 0.704-1.429 0.120 1.164 0.853-10589
  G 343(40.6) 157(34.9) 76(34.9) 0.043 0.782 0.672-1.099 0.995 0.999 0.700-1.421 0.120 0.859 0.629-1.173
rs5743810 C 12(1.4) 8(1.8) 5(2.3) 0.621 1.255 0.441-3.366 0.710 1.238 0.330-4.557 0.361 1.628 0.567-4.670
  T 832(98.6) 442(98.2) 213(97.7) 0.621 0.197 0.297-2.265 0.710 0.807 0.219-3.034 0.361 0.614 0.214-1.763
TLR_129 C 456(54.0) 258(57.3) 145(66.5) 0.255 1.143 0.774-1.251 0.023 1.478 0.674-1.335 0.001 0.932 0.689-1.261a
  G 388(46.0) 192(42.7) 73(33.5) 0.255 0.875 0.799-1.292 0.023 0.676 0.749-1.484 0.001 1.073 0.793-1.451a
rs5743836 C 231(27.4) 151(35.6) 61(28.0) 0.020 1.340 1.038-1.728 0.147 0.769 0.530-1.111 0.857 1.031 0.740-1.437
  T 613(72.6) 299(66.4) 157(72.0) 0.020 0.746 0.579-0.964 0.147 1.300 0.900-1.888 0.857 0.970 0.696-1.352
rs1870884 C 113(13.4) 58(12.9) 27(12.4) 0.800 0.957 0.669-1.359 0.855 0.955 0.563-1.591 0.696 0.914 0.584-1.433
  T 731(86.6) 392(87.1) 191(87.6) 0.800 1.044 0.736-1.494 0.855 1.047 0.629-1.777 0.696 1.094 0.698-1.713
TIRAP_975 C 723(85.7) 367(81.6) 162(74.3) 0.053 0.740 0.539-1.019 0.031 0.654 0.438-0.983a <0.001 0.484 0.338-0.694a
  T 121(14.3) 83(18.4) 56(25.7) 0.053 1.351 0.981-1.855 0.031 1.535 1.017-2.286a <0.001 2.066 1.442-2.960a
  1. PTB, pulmonary tuberculosis; LTBI, latent tuberculosis infection; HC, healthy control.
  2. ap < 0.003125 (0.05/16), the difference was statistically significant after correction for multiple testing (Bonferroni correction).