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Table 2 Distributions of toll-like receptor genotypes in the three groups

From: Screening toll-like receptor markers to predict latent tuberculosis infection and subsequent tuberculosis disease in a Chinese population

dbSNPS Genotypes Frequencies (No., %)   LTBI.vs.HC   TB.vs.LTBI   TB.vs.HC
HC ( n  = 422) LTBI ( n  = 225) TB ( n  = 109) p OR 95% CI p OR 95% CI p OR 95% CI
rs5743618 GG 2(0.5) 2(0.9) 1(0.9) 0.613 1.883 0.264-13.461 0.979 1.032 0.093-11.511 0.499 1.944 0.175-21.64
  TG 70(16.6) 23(10.2) 10(9.2) 0.028 0.573 0.347-0.946 0.763 0.887 0.407-1.936 0.054 0.508 0.252-1.022
  TT 350(82.9) 200(88.9) 98(89.9) 0.043 1.646 1.011-2.678 0.778 1.114 0.526-2.356 0.074 1.833 0.935-3.592
rs3804099 CC 51(12.1) 25(11.1) 9(8.3) 0.714 0.909 0.547-1.512 0.419 0.720 0.324-1.600 0.260 0.655 0.312-1.375
  TC 180(42.6) 95(42.2) 36(33.0) 0.916 0.982 0.708-1.363 0.107 0.675 0.418-1.089 0.068 0.663 0.426-1.033
  TT 191(45.3) 105(46.7) 64(58.7) 0.732 1.058 0.765-1.464 0.039 1.625 1.023-2.581 0.012 1.720 1.123-2.636
rs5743708 GA 4(0.9) 9(4.0) 6(5.5) 0.008 4.354 1.326-14.301 0.534 1.398 0.485-4.033 0.002 6.087 1.687-21.968a
  GG 418(99.1) 216(96.0) 103(94.5) 0.008 0.229 0.051-0.836 0.534 0.715 0.221-2.513 0.002 0.164 0.046-0.593a
rs3804100 CC 42(10.0) 45(20.0) 21(19.2) <0.001 2.262 1.433-3.570a 0.875 0.955 0.536-1.700 0.007 2.159 1.218-3.829
  TC 168(39.8) 90(40.0) 44(40.4) 0.963 1.008 0.724-1.402 0.949 1.015 0.637-1.619 0.916 1.023 0.666-1.572
  TT 212(50.2) 90(40.0) 44(40.4) 0.013 0.660 0.476-0.917 0.949 0.985 0.618-1.570 0.066 0.671 0.437-1.028
rs1898830 AA 142(33.6) 68(30.2) 33(30.3) 0.375 0.854 0.602-1.211 0.992 1.003 0.609-1.649 0.504 0.856 0.543-1.351
  AG 196(46.4) 113(50.2) 54(49.5) 0.360 1.163 0.842-1.608 0.907 0.973 0.616-1.538 0.564 1.132 0.743-1.725
  GG 84(20.0) 44(19.6) 22(20.2) 0.915 0.978 0.651-1.469 0.893 1.040 0.587-1.843 0.948 1.018 0.602-1.720
rs4986790 AA 346(82.0) 181(80.4) 77(70.6) 0.630 0.904 0.598-1.365 0.045 0.585 0.345-0.991 0.009 0.529 0.327-0.855
  AG 75(17.8) 42(18.7) 31(28.4) 0.778 1.062 0.699-1.613 0.043 1.732 1.094-3.050 0.013 1.839 1.132-2.987
  GG 1(0.2) 2(0.9) 1(0.9) 0.245 3.776 0.341-41.869 0.979 1.032 0.093-11.51 0.369 3.898 0.242-62.825
rs4986791 CC 342(81.0) 179(79.6) 74(67.9) 0.649 0.910 0.607-1.365 0.020 0.543 0.324-0.911 0.003 0.495 0.309-0.791
  CT 76(18.0) 43(19.1) 32(29.4) 0.730 1.076 0.710-1.629 0.035 1.759 1.036-2.987 0.009 1.892 1.169-3.061
  TT 4(1.0) 3(1.3) 3(2.7) 0.699 1.412 0.313-6.365 0.396 2.094 0.416-10.551 0.141 2.958 0.652-13.415
rs11536889 CC 34(8.1) 17(7.6) 10(9.2) 0.822 0.933 0.509-1.701 0.611 1.236 0.546-2.798 0.706 1.153 0.551-2.413
  GC 167(39.5) 86(38.2) 40(36.7) 0.737 0.945 0.678-1.317 0.787 0.937 0.584-1.504 0.583 0.885 0.573-1.368
  GG 221(52.4) 122(54.2) 59(54.1) 0.653 1.077 0.779-1.490 0.987 0.996 0.630-1.577 0.743 1.073 0.703-1.637
rs10759932 CC 42(10.0) 21(9.3) 5(4.5) 0.800 0.931 0.537-1.616 0.129 0.467 0.171-1.274 0.079 0.435 0.168-1.127
  TC 168(39.8) 90(40.0) 49(45.0) 0.963 1.008 0.724-1.402 0.389 1.225 0.772-1.945 0.330 1.235 0.807-1.888
  TT 212(50.2) 114(50.7) 55(50.5) 0.917 1.017 0.736-1.406 0.972 0.992 0.628-1.567 0.967 1.009 0.662-1.537
rs7873784 CC 29(6.9) 19(8.4) 7(6.4) 0.467 1.250 0.684-2.283 0.518 0.744 0.303-1.827 0.868 0.930 0.396-2.184
  GC 135(32.0) 57(25.4) 18(16.5) 0.078 0.721 0.501-1.037 0.070 0.583 0.324-1.050 0.001 0.421 0.244-0.726a
  GG 258(61.1) 149(66.2) 84(77.1) 0.202 1.246 0.888-1.748 0.043 1.714 1.014-2.897 0.002 2.136 1.312-3.478a
rs10759931 AA 143(33.9) 90(40.0) 44(40.4) 0.123 1.301 0.931-1.817 0.949 1.015 0.637-1.619 0.207 1.321 0.857-2.035
  AG 215(50.9) 113(50.2) 54(49.5) 0.860 0.971 0.703-1.343 0.907 0.973 0.616-1.538 0.793 0.945 0.620-1.440
  GG 64(15.2) 22(9.8) 11(10.1) 0.055 0.606 0.363-1.014 0.928 1.036 0.483-2.221 0.175 0.628 0.319-1.236
rs5743810 CT 12(2.8) 8(3.6) 5(4.6) 0.618 1.260 0.507-3.128 0.648 1.304 0.416-4.084 0.357 1.643 0.566-4.766
  TT 410(97.2) 217(96.4) 104(95.4) 0.618 0.790 0.293-2.276 0.648 0.773 0.215-3.057 0.357 0.609 0.210-1.766
TLR8_129 CC 133(31.5) 81(36.0) 52(47.7) 0.248 1.222 0.869-1.719 0.040 1.622 1.020-2.580 0.002 1.982 1.292-3.042a
  CG 190(45.0) 96(42.7) 41(37.6) 0.565 0.909 0.656-1.259 0.379 0.810 0.507-1.295 0.164 0.736 0.478-1.134
  GG 99(23.5) 48(21.3) 16(14.7) 0.539 0.885 0.599-1.307 0.147 0.634 0.342-1.178 0.047 0.561 0.315-0.999
rs5743836 CC 25(5.9) 13(5.8) 6(5.5) 0.940 0.974 0.488-1.943 0.919 0.950 0.351-2.571 0.868 0.925 0.370-2.314
  TC 181(42.9) 125(55.5) 49(45.0) 0.002 1.664 1.201-2.306 0.069 0.653 0.412-1.035 0.698 1.087 0.712-1.661
  TT 216(51.2) 87(38.7) 54(49.5) 0.002 0.601 0.433-0.836 0.059 1.557 0.982-2.471 0.760 0.936 0.614-1.427
rs1870884 CC 3(0.7) 1(0.4) 0(0) 1.000 0.624 0.064-6.029   -     
  TC 107(25.4) 56(24.9) 27(24.8) 0.896 0.976 0.672-1.417 0.981 0.994 0.585-1.687 0.900 0.969 0.596-1.578
  TT 312(73.9) 168(74.7) 82(75.2) 0.839 1.039 0.717-1.506 0.912 1.030 0.607-1.748 0.783 1.071 0.658-1.741
TIRAP_975 CC 313(74.2) 153(68.0) 61(56.0) 0.096 0.740 0.519-1.055 0.032 0.598 0.374-0.957 <0.001 0.443 0.286-0.685a
  CT 97(23.0) 61(27.1) 40(36.7) 0.245 1.246 0.860-1.806 0.074 1.559 0.957-2.539 0.004 1.942 1.238-3.048
  TT 12(2.8) 11(4.9) 8(7.3) 0.181 1.756 0.762-4.046 0.365 1.541 0.601-3.949 0.028 2.706 1.078-6.796
  1. PTB, pulmonary tuberculosis; LTBI, latent tuberculosis infection; HC, healthy control.
  2. ap < 0.003125 (0.05/16), the difference was statistically significant after correction for multiple testing (Bonferroni correction).