DNA damaging analysis. (A) MN frequency scored in binucleated cells. (B) Analysis of the DSBs rejoining capability of patient’s cells by PFGE after 1, 2, 6 and 24 hrs from 40 Gy X-ray treatment. (C) The number of phosphorylated H2AX (γ-H2AX) foci scored in cells treated with 1 Gy of X-rays and harvested 0.5, 6 and 24 hs later. (D) Analysis of apoptotic cells in a patient’s fibroblasts compared to HFFF2 cells.