Tissue-specific patterns of gene expression in the epithelium and stroma of normal colon in healthy individuals in an aspirin intervention trial

Table 2 Statistically significant pathways and functions in colonic epithelium and stroma

	Epithelial genes	p-value
Canonical pathways	Xenobiotic Metabolism signaling	0.000124
	Fatty acid Metabolism	0.00262
	Apoptosis Signaling	0.22
Biological function	Lipid Metabolism	6.25E-07-2.47E-02
	Small Molecule Biochemistry	6.25E-07-2.47E-02
	Molecular Transport	5.89E-05-2.47E-02
	Carbohydrate Metabolism	7.48E-04-2.47E-02
	Drug Metabolism	1.80E-03-2.47E-02
	Protein trafficking	2.34E-03-2.47E-02
	Nucleic acid Metabolism	8.58E-03-2.47E-02
	Amino acid Metabolism	1.23E-02-2.47E-02
	Stromal genes	p-value
Canonical pathways	Complement System	2.49E-08
	Antigen Presentation Pathway	0.00000018
	IL-4 signaling	0.0000656
Biological function	Inflammation	8.74E-28-8.17E-06
	Cell-to-cell signaling	1.90E-27-1.09E-05
	Immunological Disease	5.34E-25-4.44E-06
	Hematological System Development & Function	4.50E-19-1.12E-05
	Immune Response	4.50E-19-1.12E-05

Ingenuity Pathway Analysis of selected biological functional groups and metabolic and signaling pathways for all statistically significant genes of both tissue types. Range of p-values indicates the significance values of the specific sub-functions associated with that particular high-level function. Italic font indicates function was unique to that particular tissue type and was essentially not expressed in the other tissue.

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