From: Impact of PTBP1 rs11085226 on glucose-stimulated insulin release in adult Danes
Additive inheritance | Dominant inheritance | |||||||
---|---|---|---|---|---|---|---|---|
Fixed effect model | Random effect model | Fixed effect model | Random effect model | |||||
Combined effect | P | Combined effect | P | Combined effect | P | Combined effect | P | |
β-cell responsiveness to glucose (pmol · kg−1 · min−1/mmol · l) | 0.054 (−0.097; 0.21) | 0.5 | 0.038 (−0.23; 0.30) | 0.8 | −0.11 (−0.20; −0.025) | 0.01 | −0.13 (−0.25; 0.003) | 0.06 |
Fasting ISR (pmol · kg−1 · min−1) | 0.037 (−0.057; 0.13) | 0.4 | 0.037 (−0.057; 0.13) | 0.4 | 0.65 (−2.62; 3.92) | 0.7 | 0.56 (−4.57; 5.69) | 0.8 |
Disposition index* | −0.11 (−0.302; 0.081) | 0.25 | 0.51 (−0.99; 2.014) | 0.5 | −0.1030 (−0.299; 0.093) | 0.3 | 0.51(−0.982; 2.011) | 0.96 |
AUC ISR0–8 min * (pmol · kg−1) | −0.0015 (−0.082; 0.079) | 0.97 | −0.0015 (−0.082; 0.079) | 0.97 | −0.060 (−0.16; 0.043) | 0.3 | −0.081 (−0.27; 0.11) | 0.4 |
IncAUC ISR0–8 min (pmol · kg−1) | 0.003 (−0.097; 0.10) | 0.95 | 0.003 (−0.097; 0.10) | 0.95 | 0.010 (−0.051; 0.072) | 0.7 | 0.010 (−0.051; 0.072) | 0.7 |
AUC insulin0–8 min * (pmol/l · min) | −0.043 (−0.15; 0.068) | 0.4 | −0.043 (−0.15; 0.068) | 0.4 | −0.094 (−0.29; 0.11) | 0.4 | −0.094 (−0.29; 0.11) | 0.4 |
Acute phase insulin response (pmol/l · min) | −85.40 (−381.20; 210.41) | 0.6 | −74.47 (−407.35; 258.41) | 0.7 | 16.73 (−215.63; 249.09) | 0.9 | 3.30 (−288.95; 295.55) | 0.98 |
AUC glucose0–8 min (mmol/l · min) | 0.39 (−1.42; 2.20) | 0.7 | 0.11 (−2.69; 2.91) | 0.9 | 19.82 (−202.28; 241.92) | 0.9 | −5.020 (−338.55; 328.51) | 0.98 |
IncAUC glucose0–8 min (mmol/l · min) | 0.36 (−1.2163; 1.9341) | 0.66 | 0.35 (−1.27; 1.96) | 0.7 | 0.02 (−1.42; 1.46) | 0.98 | 0.16(−2.22; 2.55) | 0.9 |
AUC C-peptide0–8 min* (pmol/l · min) | −0.0019 (−0.063; 0.059) | 0.95 | −0.0019 (−0.0632; 0.0594) | 0.95 | −0.0268 (−0.124; 0.0701) | 0.6 | −0.0336(−0.1582; 0.0910) | 0.6 |
Acute phase C-peptide response (pmol/l · min) | 7.69 (−582.011; 597.39) | 0.98 | 10.081 (−586.71; 606.87) | 0.97 | 176.92 (−357.81; 711.66) | 0.5 | 176.92 (−357.81; 711.66) | 0.5 |