Table 2 Quantitative metabolic traits in up to 13,605 non-diabetic Danish Caucasian subjects stratified according to genotype
From: Impact of PTBP1 rs11085226 on glucose-stimulated insulin release in adult Danes
n | AA | AG | GG | P add | P dom | |
|---|---|---|---|---|---|---|
Glycated hemoglobin | ||||||
HbA1c (%)¤ | 13251 (11071/2099/81) | 5.61 (0.41) | 5.60 (0.41) | 5.56 (0.39) | 0.14 (0.15) | 0.19 (0.22) |
Plasma glucose | ||||||
Glu0 (mmol/l) | 13599 (11378/2139/82) | 5.47 (0.53) | 5.48 (0.51) | 5.49 (0.55) | 0.26 (0.28) | 0.23 (0.26) |
Glu30 (mmol/l)¤ | 5522 (4631/860/31) | 8.58 (1.70) | 8.52 (1.74) | 8.66 (1.51) | 0.85 (0.76) | 0.95 (0.61) |
Glu120 (mmol/l)¤ | 6155 (5180/942/33) | 5.96 (1.55) | 5.93 (1.50) | 5.90 (1.62) | 0.90 (0.58) | 0.90 (0.60) |
AUC Glu (mmol/l·min) ¤ | 5510 (4621/858/31) | 864.70 (144.86) | 863.19 (138.62) | 862.84 (121.30) | 0.99 (0.65) | 0.97 (0.56) |
Serum insulin | ||||||
Ins0 (pmol/l)¤ | 8944 (7504/1388/52) | 40.87 (26.56) | 40.17 (25.43) | 39.84 (24.64) | 0.43 (0.29) | 0.41 (0.32) |
Ins30 (pmol/l)¤ | 5342 (4468/844/30) | 293.95 (187.55) | 287.32 (172.96) | 271.67 (133.03) | 0.92 (0.99) | 0.95 (0.92) |
Ins120 (pmol/l)¤ | 5450 (4570/850/30) | 207.13 (198.16) | 210.64 (207.43) | 188.53 (143.48) | 0.55 (0.69) | 0.52 (0.64) |
AUCIns (pmol/l · min) | 5045 (4227/791/27) | 27795.2 (17784.9) | 27412.34 (17018.2) | 26148.89 (12052.43) | 0.49 (0.90) | 0.51 (0.93) |
Indices of insulin secretion and beta-cell function | ||||||
DI ¤ | 5031 (4216/788/27) | 171.94 (73.12) | 171.53 (72.63) | 176.99 (86.879) | 0.37 | 0.35 |
BIGTT-AIR | 5030 (4215/788/27) | 1916.03 (2484.30) | 1823.89 (1038.50) | 1718.15 (578.42) | 0.57 (0.49) | 0.58 (0.50) |
CIR ¤ | 5270 (4408/832/30) | 872.79 (729.90) | 874.15 (731.58) | 734.96 (443.06) | 0.87 (0.87) | 0.91 (0.83) |
HOMA-B ¤ | 8927 (7489/1386/52) | 63.75 (48.62) | 61.75 (36.81) | 62.66 (41.39) | 0.96 (0.65) | 0.93 (0.75) |
AUC Ins(0–30) /AUC Glu(0–30) ¤ | 5174 (4331/814/29) | 23.97 (13.84) | 23.66 (13.11) | 22.43 (8.91) | 0.94 (0.97) | 0.89 (0.94) |
IGI ¤ | 5109 (4276/84/29) | 104.38 (117.23) | 108.27 (133.32) | 81.24 (52.88) | 0.67 (0.77) | 0.58 (0.69) |
AUC C-pep /AUC Glu ¤ | 5480 (4597/854/29) | 268.18 (79.58) | 269.96 (81.90) | 256.53 (61.19) | 0.39 (0.55) | 0.31(0.50) |