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Table 1 Association analysis of type 2 diabetes and PTBP1 rs11085226 in 5,634 type 2 diabetes patients and 4,641 glucose-tolerant control subjects

From: Impact of PTBP1 rs11085226 on glucose-stimulated insulin release in adult Danes

 

Genotype distribution

Additive model

Dominant model

 

NGT

T2D

OR

P

OR

P

N

4641

5634

1.13 (0.88 - 1.46)

0.33a

1.14 (0.87 - 1.49)

0.33a

AA

3874 (83.5)

4741 (84.1)

    

AG

739 (15.9)

848 (15.1)

    

GG

28 (0.6)

45 (0.8)

    

MAF

8.6 (8.0 – 9.1)

8.3 (7.8 – 8.8)

0.97 (0.88 - 1.07)

0.55b

  
  1. Data are number of subjects in each genotype group (% of each group) and MAF in % (95% CI). OR (95% CI) and P-values for genotype distribution were calculated using logistic regression with adjustment for sex, age, BMI and study group (a). OR (95% CI) and P-values for allele frequency were calculated using Fisher’s exact test (b). Analyses were conducted for men and women combined assuming either an additive or dominant inheritance model. NGT: Normal glucose tolerance. T2D: Type 2 diabetes.
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BMC Medical Genetics

ISSN: 1471-2350

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