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Table 4 Association analyses between left ventricular mass indexed by BSA and nine candidate SNPs from the HyperGEN study in the Korean population

From: Validation study of candidate single nucleotide polymorphisms associated with left ventricular hypertrophy in the Korean population

  

Log (LVM/BSA)

LVH

SNP

LVM/BSA, g/m 2

Beta§

L95

U95

P value

OR§

L95

U95

P value

rs409045

 

−0.023

0.048

0.001

0.060

0.787

0.601

1.031

0.083

TT (n = 1239)

95.9 ± 22.5

        

CT + CC (n = 398)

94.3. ± 22.3

        

rs6450415

 

0.018

−0.004

0.041

0.107

1.463

1.148

1.865

0.002

TT (n = 1118)

95.2 ± 22.5

        

CT + CC (n = 519)

96.4 ± 22.3

        

rs6961069

 

0.001

−0.020

0.022

0.932

1.190

0.946

1.496

0.137

TT (n = 808)

95.5 ± 21.8

        

CT + CC (n = 829)

95.6 ± 23.1

        

rs10499859

 

0.001

−0.020

0.022

0.945

1.180

0.938

1.484

0.156

AA (n = 799)

95.6 ± 21.8

        

AG + GG (n = 838)

95.4 ± 23.1

        

rs4129218

 

−0.023

−0.044

−0.001

0.036

0.766

0.605

0.970

0.027

AA (n = 975)

96.6 ± 23.0

        

AG + GG (n = 662)

94.0 ± 21.5

        

rs1155635

 

−0.002

−0.025

0.020

0.831

0.905

0.710

1.153

0.420

AA (n = 543)

95.8 ± 22.5

        

GA + GG (n = 1081)

95.5 ± 22.5

        

rs2415872

 

−0.013

−0.034

0.008

0.236

0.855

0.680

1.075

0.181

GG (n = 735)

96.2 ± 22.4

        

GC + CC (n = 902)

95.0 ± 22.5

        

rs756529

 

0.015

−0.007

0.037

0.173

1.234

0.972

1.568

0.085

AA (n = 609)

94.4 ± 21.7

        

GA + GG (n = 1028)

96.3 ± 22.9

        

rs10483186

 

−0.006

−0.027

0.016

0.586

0.999

0.790

1.264

0.996

GG (n = 622)

96.2 ± 23.0

        

GT + TT (n = 1015)

95.2 ± 22.1

        
  1. §Analysis adjusted for age, gender, body mass index, serum creatinine, systolic blood pressure, heart rate and antihypertensive medication.
  2. Abbreviations: L95 and U95, confidence interval lower and upper 95%; LVH, left ventricular hypertrophy defined as LVM/BSA ≥ 116 g/m2 in males and ≥ 96 g/m2 in females; LVM/BSA, left ventricular mass indexed by body surface area; SNP, single nucleotide polymorphism.
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BMC Medical Genetics

ISSN: 1471-2350

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