Table 5 Combined effects of CYP2C19 polymorphism and environmental factors
Exposure | CYP2C19*2 | Patients n (%) | Controls n (%) | Adjusted OR (95% CI) a | P value for multiplicative interaction a | ICR (95% CI) a |
|---|---|---|---|---|---|---|
Tea drinking | 0.04 | -1.77 (-3.92 ~ 0.38) | ||||
Never | GG | 25 (8.77) | 136 (23.86) | Reference | ||
Never | GA/AA | 104 (36.49) | 157 (27.54) | 4.17 (2.46 ~ 7.08) | ||
Ever | GG | 34 (11.93) | 107 (18.77) | 0.52 (0.32 ~ 0.84) | ||
Ever | GA/AA | 122 (42.81) | 170 (29.82) | 1.92 (1.41 ~ 2.63) | ||
Alcohol drinking | 0.051 | -1.79 (-4.04 ~ 0.46) | ||||
Never | GG | 40 (14.04) | 197 (34.56) | Reference | ||
Never | GA/AA | 180 (63.16) | 254 (44.56) | 3.63 (2.39 ~ 5.51) | ||
Ever | GG | 19 (6.67) | 46 (8.07) | 2.32 (1.15 ~ 4.71) | ||
Ever | GA/AA | 46 (16.14) | 73 (12.81) | 2.86 (1.60 ~ 5.10) | ||
Smoking | 0.48 | 1.180 (-1.21 ~ 3.57) | ||||
Never | GG | 30 (10.53) | 134 (23.51) | Reference | ||
Never | GA/AA | 100 (35.09) | 147 (25.79) | 3.41 (2.09 ~ 5.57) | ||
Ever | GG | 29 (10.18) | 109 (19.12) | 2.23 (1.01 ~ 4.94) | ||
Ever | GA/AA | 126 (44.21) | 180 (31.58) | 5.82 (2.80 ~ 12.09) | ||
Intake of fresh fruits and vegetables (g/day) | 0.10 | 1.92 (-5.15 ~ 1.31) | ||||
<400 | GG | 55 (19.30) | 212 (37.19) | Reference | ||
<400 | GA/AA | 222 (77.89) | 295 (51.75) | 2.94 (2.04 ~ 4.24) | ||
≥400 | GG | 4 (1.40) | 31 (5.44) | 0.41 (0.134 ~ 1.27) | ||
≥400 | GA/AA | 4 (1.40) | 32 (5.61) | 0.43 (0.14 ~ 1.33) | ||
Pickled vegetables | 0.12 | 1.96 (0.12 ~ 3.80) | ||||
Never | GG | 32 (11.23) | 150 (26.32) | Reference | ||
Never | GA/AA | 103 (36.14) | 205 (35.96) | 2.55 (1.61 ~ 4.06) | ||
Ever | GG | 27 (9.47) | 93 (16.32) | 1.66 (0.90 ~ 3.04) | ||
Ever | GA/AA | 123 (43.16) | 122 (21.40) | 5.17 (3.21 ~ 8.33) | ||
Hot Beverage and food intake | 6.98 × 10-6 | -0.66 (-6.42 ~ 5.10) | ||||
Never | GG | 12 (4.21) | 167 (29.30) | Reference | ||
Never | GA/AA | 99 (34.74) | 192 (33.68) | 7.64 (3.90 ~ 14.94) | ||
Ever | GG | 47 (16.49) | 76 (13.33) | 9.87 (4.67 ~ 20.85) | ||
Ever | GA/AA | 127 (44.56) | 135 (23.68) | 15.85 (7.78 ~ 32.30) | ||