Table 5 Functional significance of mutation prediction done by using PolyPhen-2, PMut and SIFT
From: c.620C>T mutation in GATA4 is associated with congenital heart disease in South India
| Â | P394T | D425N | ||
|---|---|---|---|---|
Name of software | Prediction | Score | Prediction | Score |
PolyPhen-2 | Benign | 0.025 | Possibly damaging | 0.972 |
PMut | Neutral | 0.4499 | Pathological | 0.6236 |
SIFT | Tolerated | 0.55 | Not Tolerated | 0.24 |