Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer

Table 2 Relative effects of HMIP-2 haplotypes on the ln[HbF%] trait

Compared haplotypes	Difference	lower	upper	p adjusted
a-B₁ vs. a-b	0.029	−0.35	0.40	1.00
a-B ₂ vs. a-b	0.431	0.08	0.78	7 x 10 ⁻³
a-B ₃ vs. a-b	0.332	0.01	0.66	0.04
A-b vs. a-b	0.636	0.10	1.18	0.01
A-B vs. a-b	0.638	−0.10	1.38	0.13
a-B₁ vs. a-B₂	−0.401	−0.10	0.90	0.20
a-B₁ vs. a-B₃	−0.303	−0.79	0.18	0.47
a-B₂ vs. a-B₃	0.098	−0.37	0.56	0.99
a-B₁ vs. A-b	−0.607	−1.25	0.04	0.08
a-B₂ vs. A-b	−0.205	−0.84	0.43	0.94
a-B₃ vs. A-b	−0.304	−0.92	0.32	0.73
A-B vs. A-b	0.002	−0.91	0.91	1.00
a-B₁ vs. A-B	−0.609	−1.43	0.21	0.28
a-B₂ vs. A-B	−0.208	−1.02	0.60	0.98
a-B₃ vs. A-B	−0.306	−1.10	0.49	0.88

“Difference” represents the difference in effect size between the two haplotypes on log-transformed HbF levels; negative difference values indicates that the effect size of the second haplotype is bigger than that of the first. ‘lower’ and ‘upper’ represent boundaries for family-wise 95% confidence intervals. ‘p adjusted’ is the P-value adjusted for age, sex as well as multiple testing.
Three haplotypes (shown in bold) have significant HbF-boosting effects at the 0.05 level.

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