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Figure 1 | BMC Medical Genetics

Figure 1

From: Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer

Figure 1

Association of common genetic variation with HbF levels across theHBS1L-MYBintergenic region on chromosome 6q23.3. Shown are LOP (−log10 [P-value]) scores for 1,022 patients, tested for association of ln[%HbF] with 109 common variants from a combination of Illumina Human Omnichip 2.5 data and PCR-based genotyping. A: Genetic association is present over the entire interval, but reaches genome-wide significance only at HMIP-2, whereas the other two LD blocks detected in Europeans (HMIP-1 and HMIP-3,[8]) display only low-level association in our dataset. B: HbF association at HMIP-2. The six SNPs showing strong association are indicated. In addition to un-conditioned analysis (black dots), the presence two partially independent association signals (sub-loci HMIP-2A and HMIP-32B) is shown by conditioning analysis on rs66650371 (tagging HMIP-2A, black diamonds) and rs9494145 (tagging HMIP-2B, open diamonds, see also Table 1).

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