Timeline of a rectal cancer patient with theBRAF VK600–601Emutation. The left lower image shows the findings of the histopathological examination of the resected tumor following initial surgery in 2007, revealing a moderately to poorly differentiated adenocarcinoma. PET/CT slices show recurrent tumors; progressive perineal metastatic tumor (the white arrow) and right obturator and right internal iliac lymph node metastases (the red arrows). The tumors had infiltrated into the right internal iliac artery and right urinary duct. The perineal metastatic tumor was enlarged and had invaded the bladder (yellow arrow).