| | | |
Recessive model
|
Dominant model
|
Homozygote
|
Heterozygote
|
|---|
| | | |
GG vs. AG + AA
|
GG + AG vs. AA
|
GG vs. AA
|
AG vs. AA
|
|
Clinical variable
|
n
|
SNP
|
OR (95% CI)
|
P
|
OR (95% CI)
|
P
|
OR (95% CI)
|
P
|
OR (95% CI)
|
P
|
|
cT, 1a-2a/2b-4
|
270/207
|
rs11615
|
1.02 (0.62 – 1.68)
|
0.928
|
0.50 (0.35 – 0.73)
|
<0.0001
|
0.67 (0.39 – 1.16)
|
0.152
|
0.45 (0.30 – 0.70)
|
<0.0001
|
| | | |
GG vs. GT + TT
|
GG + GT vs. TT
|
GG vs. TT
|
GT vs. TT
|
| | | |
OR (95% CI)
|
P
|
OR (95% CI)
|
P
|
OR (95% CI)
|
P
|
OR (95% CI)
|
P
|
|
Gleason, <7/ ≥ 7
|
226/266
|
rs17503908
|
NA
|
–
|
0.48 (0.30 – 0.76)
|
0.002
|
NA
|
–
|
0.45 (0.28 – 0.72)
|
0.001
|
-
Abbreviations: OR odds ratio, CI confidence interval, NA not applicable (due to the limited sample size: only 2 subjects genotyped as GG-rs17503908).
- Statistical test: binary logistic regression (Reference category for SNP rs11615: AA. Reference category for SNP rs17503908: TT).
