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Table 3 Univariate analysis for polymorphisms rs11615 ( ERCC1 ) and rs17503908 ( ATM ) and clinical variables

From: Single nucleotide polymorphisms in DNA repair genes as risk factors associated to prostate cancer progression

   

Recessive model

Dominant model

Homozygote

Heterozygote

   

GG vs. AG + AA

GG + AG vs. AA

GG vs. AA

AG vs. AA

Clinical variable

n

SNP

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

cT, 1a-2a/2b-4

270/207

rs11615

1.02 (0.62 – 1.68)

0.928

0.50 (0.35 – 0.73)

<0.0001

0.67 (0.39 – 1.16)

0.152

0.45 (0.30 – 0.70)

<0.0001

   

GG vs. GT + TT

GG + GT vs. TT

GG vs. TT

GT vs. TT

   

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

Gleason, <7/ ≥ 7

226/266

rs17503908

NA

0.48 (0.30 – 0.76)

0.002

NA

0.45 (0.28 – 0.72)

0.001

  1. Abbreviations: OR odds ratio, CI confidence interval, NA not applicable (due to the limited sample size: only 2 subjects genotyped as GG-rs17503908).
  2. Statistical test: binary logistic regression (Reference category for SNP rs11615: AA. Reference category for SNP rs17503908: TT).