The impact of coronary artery disease risk loci on ischemic heart failure severity and prognosis: association analysis in the COntrolled ROsuvastatin multiNAtional trial in heart failure (CORONA)

Table 4 CAD loci ( P < 0.05) and lipid characteristics in genetic sub-study of CORONA

	Locus	SNP	Model	n	Beta estimate	95% CI	P value
Total cholestorol (mmol/L)	1p13.3	rs599839	Unadj.	3,285	−0.14	−0.20 - -0.08	1.2 × 10⁻⁵
			Adj.^a	2,219	−0.14	−0.21 - -0.07	1.1 × 10⁻⁴
	10q11.21	rs501120	Unadj.	3,285	−0.07	−0.15 - -0.001	4.7 × 10⁻²
			Adj.^a	2,217	−0.05	−0.13 - 0.03	0.24
LDL cholesterol (mmol/L)	1p13.3	rs599839	Unadj.	3,285	−0.16	−0.22 - -0.11	1.8 × 10⁻⁹
			Adj.^a	2,219	−0.17	−0.23 - -0.1	3.5 × 10⁻⁷
	10q11.21	rs501120	Unadj.	3,285	−0.07	−0.13 - -0.004	3.6 × 10⁻²
			Adj.^a	2,217	−0.05	−0.12 - 0.02	0.19
Triglycerides (mmol/L)	1p13.3	rs599839	Unadj.	3,285	0.08	0.007 - 0.15	3.2 × 10⁻²
			Adj.^a	2,219	0.07	−0.005 - 0.15	6.6 × 10⁻²
	9p21.3	rs1333049	Unadj.	3,285	−0.08	−0.14 - -0.02	7.0 × 10⁻³
			Adj.^a	2,213	−0.06	−0.13 - 0.001	5.4 × 10⁻²
Apo-B (g/L)	1p13.3	rs599839	Unadj.	3,264	−0.06	−0.07 - -0.04	2.2 × 10⁻¹⁰
			Adj.^a	2,218	−0.06	−0.08 - -0.04	5.1 × 10⁻⁸
	10q11.21	rs501120	Unadj.	3,267	−0.02	−0.04 - -0.002	2.8 × 10⁻²
			Adj.^a	2,216	−0.02	−0.05 - 0.002	7.5 × 10⁻²
Apo-B/Apo-A1 ratio	1p13.3	rs599839	Unadj.	3,264	−0.05	−0.06 - -0.03	3.3 × 10⁻¹¹
			Adj.^a	2,218	−0.05	−0.07 - -0.03	8.0 × 10⁻⁹

Abbreviations: SNP single nucleotide polymorphism, LDL low-density-lipoprotein, HDL high-density-lipoprotein, Apo-B apolipoprotein-B, Apo-A1 apolipoprotein-A1. ^aAdjusted analyses were adjusted for age, sex, ejection fraction, NYHA class, systolic blood pressure, heart rate, body mass index, history of myocardial infarction, angina pectoris, diabetes mellitus, hypertension, stroke, intermittent claudication, aortic aneurysm, percutaneous coronary intervention, coronary artery bypass graft surgery, atrial fibrillation, implanted pacemaker, implanted cardiac defibrillator, smoking status, serum creatinine, alanine aminotransferase, creatine kinase, thyroid-stimulating hormone, triglycerides, hsCRP and NT-proBNP [10]. As some covariates were also baseline variables or strongly associated to a baseline variable, covariates were excluded from analysis (see Additional file 3: Table S2). Data for all SNPs are presented in Additional file 7: Table S6.

ISSN: 1471-2350