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Table 2 Hazard ratio for incident CVD in the Malmö Diet and Cancer Study (n = 23,949) according to rs4977574 genotype and dietary or alcohol intake categories

From: The chromosome 9p21 variant interacts with vegetable and wine intake to influence the risk of cardiovascular disease: a population based cohort study

  Hazard ratio (95% Confidence interval) P trend b,d P interaction e,f
AA AG GG Additive model b,d
  n 7325 11777 4847    
Vegetables (g/day)        0.043, 0.049
 Low 7952 1.29 (1.09–1.52) 1.22 (1.04–1.43) 1.50 (1.26–1.79) 1.06 (0.98–1.14) 0.16  
 Medium 8041 0.87 (0.73–1.05) 1.27 (1.09–1.48) 1.41 (1.18–1.70) 1.27 (1.17–1.38) 5.6 × 10−8  
 High 7956 1.00 (ref)a,e 1.20 (1.02–1.41) 1.43 (1.18–1.72) 1.19 (1.08–1.30) 0.0004  
  Per categoryc,e   0.86 (0.79–0.94) 0.98 (0.92–1.05) 0.99 (0.90–1.09)    
  Ptrend c,e   0.001 0.61 0.83    
Fruits (g/day)        0.69, 0.80
 Low 7886 1.10 (0.93–1.30) 1.26 (1.09–1.46) 1.51 (1.27–1.80) 1.16 (1.07–1.26) 0.0004  
 Medium 8030 1.13 (0.96–1.34) 1.25 (1.08–1.45) 1.46 (1.23–1.74) 1.14 (1.04–1.24) 0.003  
 High 8033 1.00 (ref) 1.24 (1.07–1.44) 1.44 (1.21–1.72) 1.18 (1.08–1.29) 0.0002  
  Per category   0.97 (0.89–1.06) 0.98 (0.92–1.05) 1.00 (0.90–1.10)    
  Ptrend   0.48 0.52 0.92    
Wine (g/day)        0.029, 0.031
 Non-consumers 6843 1.03 (0.86–1.22) 1.27 (1.09–1.49) 1.57 (1.32–1.88) 1.23 (1.14–1.34) 4 × 10−7  
 Low 8472 0.93 (0.78–1.11) 1.14 (0.98–1.33) 1.29 (1.08–1.59) 1.16 (1.07–1.26) 0.0004  
 High 8634 1.00 (ref) 1.01 (0.87–1.17) 1.17 (0.98–1.40) 1.08 (0.98–1.18) 0.11  
  Per category   0.97 (0.88–1.08) 0.91 (0.85–0.98) 0.84 (0.75–0.93)    
  Ptrend   0.61 0.01 0.001    
Alcohol (g/day)        0.73, 0.86
 Abstainers 1448 1.19 (0.78–1.81) 1.63 (1.11–2.39) 2.26 (1.49–3.42) 1.34 (1.13–1.60) 0.001  
 Low 17331 1.14 (0.81–1.60) 1.36 (0.97–1.91) 1.47 (1.04–2.08) 1.14 (1.07–1.20) 0.00002  
 Medium 4150 1.18 (0.81–1.70) 1.06 (0.74–1.52) 1.64 (1.13–2.37) 1.15 (1.02–1.30) 0.03  
 High 1020 1 (ref) 1.23 (0.82–1.85) 1.57 (0.99–2.50) 1.29 (1.02–1.63) 0.04  
  Per category   0.98 (0.87–1.10) 0.85 (0.78–0.93) 0.96 (0.85–1.09)    
  Ptrend   0.74 0.0004 0.57    
  1. aMultivariable Cox proportional hazards model for incidence of cardiovascular disease (CVD) during follow-up with hazard ratio per each category of rs4977574 genotype and food or beverage intake assuming the highest category and AA genotype as reference.
  2. bMultivariable Cox proportional hazards model for incidence of cardiovascular disease (CVD) during follow-up with hazard ratio per risk G allele using an additive genetic model.
  3. cMultivariable Cox proportional hazards model for incidence of cardiovascular disease (CVD) during follow-up with hazard ratio per each higher food or beverage intake category with the lowest intake category as reference.
  4. dAdjusted for age and sex.
  5. eAdjusted for age, sex, BMI, SBP, season, method, total energy intake, leisure time physical activity, alcohol intake, smoking status, education, lipid lowering and antihypertensive treatment.
  6. fExcluding BMI, SBP, antihypertensive and lipid lowering treatment from the adjustment model.