Table 2 Hazard ratio for incident CVD in the Malmö Diet and Cancer Study (n = 23,949) according to rs4977574 genotype and dietary or alcohol intake categories

n

7325

11777

4847

Vegetables (g/day)

0.043, 0.049

 Low

7952

1.29 (1.09–1.52)

1.22 (1.04–1.43)

1.50 (1.26–1.79)

1.06 (0.98–1.14)

0.16

 Medium

8041

0.87 (0.73–1.05)

1.27 (1.09–1.48)

1.41 (1.18–1.70)

1.27 (1.17–1.38)

5.6 × 10⁻⁸

 High

7956

1.00 (ref)^a,e

1.20 (1.02–1.41)

1.43 (1.18–1.72)

1.19 (1.08–1.30)

0.0004

  Per category^c,e

0.86 (0.79–0.94)

0.98 (0.92–1.05)

0.99 (0.90–1.09)

  P_trend ^c,e

0.001

0.61

0.83

Fruits (g/day)

0.69, 0.80

 Low

7886

1.10 (0.93–1.30)

1.26 (1.09–1.46)

1.51 (1.27–1.80)

1.16 (1.07–1.26)

0.0004

 Medium

8030

1.13 (0.96–1.34)

1.25 (1.08–1.45)

1.46 (1.23–1.74)

1.14 (1.04–1.24)

0.003

 High

8033

1.00 (ref)

1.24 (1.07–1.44)

1.44 (1.21–1.72)

1.18 (1.08–1.29)

0.0002

  Per category

0.97 (0.89–1.06)

0.98 (0.92–1.05)

1.00 (0.90–1.10)

  P_trend

0.48

0.52

0.92

Wine (g/day)

0.029, 0.031

 Non-consumers

6843

1.03 (0.86–1.22)

1.27 (1.09–1.49)

1.57 (1.32–1.88)

1.23 (1.14–1.34)

4 × 10⁻⁷

 Low

8472

0.93 (0.78–1.11)

1.14 (0.98–1.33)

1.29 (1.08–1.59)

1.16 (1.07–1.26)

0.0004

 High

8634

1.00 (ref)

1.01 (0.87–1.17)

1.17 (0.98–1.40)

1.08 (0.98–1.18)

0.11

  Per category

0.97 (0.88–1.08)

0.91 (0.85–0.98)

0.84 (0.75–0.93)

  P_trend

0.61

0.01

0.001

Alcohol (g/day)

0.73, 0.86

 Abstainers

1448

1.19 (0.78–1.81)

1.63 (1.11–2.39)

2.26 (1.49–3.42)

1.34 (1.13–1.60)

0.001

 Low

17331

1.14 (0.81–1.60)

1.36 (0.97–1.91)

1.47 (1.04–2.08)

1.14 (1.07–1.20)

0.00002

 Medium

4150

1.18 (0.81–1.70)

1.06 (0.74–1.52)

1.64 (1.13–2.37)

1.15 (1.02–1.30)

0.03

 High

1020

1 (ref)

1.23 (0.82–1.85)

1.57 (0.99–2.50)

1.29 (1.02–1.63)

0.04

  Per category

0.98 (0.87–1.10)

0.85 (0.78–0.93)

0.96 (0.85–1.09)

  P_trend

0.74

0.0004

0.57