Skip to main content

Table 1 Characteristics of the Malmö Diet and Cancer Study population by rs4977574 genotype

From: The chromosome 9p21 variant interacts with vegetable and wine intake to influence the risk of cardiovascular disease: a population based cohort study

 

rs4977574 genotype

HR (95% CI) a

P trend

AA

AG

GG

or β (SE) b

Total number

7325

11777

4847

  

Sex (%women)

62.6

62.3

62.3

  

Incident CVD N (%)

863 (11.8)

1562 (13.3)

739 (15.3)

1.16 (1.10-1.22)

4 × 10−09

Age (years)

57.9 ± 7.7

57.9 ± 7.6

57.8 ± 7.7

−0.04 (0.07)

0.60

BMI (kg/m2)

25.7 ± 3.9

25.6 ± 3.9

25.7 ± 3.9

0.001 (0.035)

0.98

Waist (cm)

83.6 ± 15.6

83.4 ± 12.8

83.7 ± 16.7

0.02 (0.11)

0.87

SBP (mmHg)

141 ± 20

141 ± 20

141 ± 20

0.21 (0.17)

0.21

DBP (mmHg)

85 ± 10

85 ± 10

86 ± 10

0.03 (0.09)

0.76

FPG (mmol/L)c

5.63 ± 0.84

5.62 ± 0.72

5.66 ± 0.91

0.009 (0.016)

0.59

HbA1C (mmol/mol)c

39.6 ± 4.94

39.6 ± 4.82

39.9 ± 5.32

0.13 (0.10)

0.19

LDLC (mmol/L)c

4.15 ± 1.00

4.19 ± 0.98

4.19 ± 0.97

0.02 (0.02)

0.33

HDLC (mmol/L)c

1.39 ± 0.37

1.40 ± 0.38

1.39 ± 0.36

0.001 (0.007)

0.85

Triglycerides (mmol/L)c

1.35 ± 0.73

1.32 ± 0.71

1.37 ± 0.90

0.002 (0.015)

0.48

hsCRPc

0.26 ± 0.43

0.24 ± 0.39

0.27 ± 0.48

0.003 (0.009)

0.67

Total energy intake (kcal/day)

2280 ± 652

2274 ± 653

2276 ± 653

−3.90 (5.26)

0.46

Vegetables (g/day)

180 ± 98

182 ± 100

180 ± 99

−0.18 (0.90)

0.85

Fruits (g/day)

196 ± 127

193 ± 125

197 ± 127

0.29 (1.14)

0.80

Wine (g/day)

41.2 ± 58.2

42.8 ± 70.0

42.5 ± 60.6

0.70 (0.55)

0.20

Alcohol (g/day)

10.6 ± 12.3

10.9 ± 12.7

10.8 ± 12.8

0.13 (0.11)

0.22

  1. Data represented as mean ± standard deviation.
  2. aMultivariable Cox proportional hazards model for incidence of cardiovascular disease (CVD) during follow-up adjusting for age and sex with HR referring to hazard ratio per risk G allele using an additive genetic model.
  3. bLinear regression analyses of rs4977574 G allele using an additive genetic model with quantitative traits or characteristics at baseline adjusting for age and sex when appropriate with β referring to associated effect estimate per risk G allele.
  4. cIn MDC-CC only, N = 4,828 (AA N = 1,460; AG N = 2,381; GG N = 987).
  5. CI, Confidence Interval; CVD, cardiovascular disease; SE, standard error; BMI, Body Mass Index; SBP, Systolic Blood Pressure; DBP, Diastolic Blood Pressure; FPG, Fasting Plasma Glucose; HbA1C, Hemoglobin A1C; LDLC, Low-Density Lipoprotein Cholesterol; HDLC, High-Density Lipoprotein Cholesterol; hsCRP, High-Sensitivity C-Reactive Protein.