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Table 1 Characteristics of the Malmö Diet and Cancer Study population by rs4977574 genotype

From: The chromosome 9p21 variant interacts with vegetable and wine intake to influence the risk of cardiovascular disease: a population based cohort study

  rs4977574 genotype HR (95% CI) a P trend
AA AG GG or β (SE) b
Total number 7325 11777 4847   
Sex (%women) 62.6 62.3 62.3   
Incident CVD N (%) 863 (11.8) 1562 (13.3) 739 (15.3) 1.16 (1.10-1.22) 4 × 10−09
Age (years) 57.9 ± 7.7 57.9 ± 7.6 57.8 ± 7.7 −0.04 (0.07) 0.60
BMI (kg/m2) 25.7 ± 3.9 25.6 ± 3.9 25.7 ± 3.9 0.001 (0.035) 0.98
Waist (cm) 83.6 ± 15.6 83.4 ± 12.8 83.7 ± 16.7 0.02 (0.11) 0.87
SBP (mmHg) 141 ± 20 141 ± 20 141 ± 20 0.21 (0.17) 0.21
DBP (mmHg) 85 ± 10 85 ± 10 86 ± 10 0.03 (0.09) 0.76
FPG (mmol/L)c 5.63 ± 0.84 5.62 ± 0.72 5.66 ± 0.91 0.009 (0.016) 0.59
HbA1C (mmol/mol)c 39.6 ± 4.94 39.6 ± 4.82 39.9 ± 5.32 0.13 (0.10) 0.19
LDLC (mmol/L)c 4.15 ± 1.00 4.19 ± 0.98 4.19 ± 0.97 0.02 (0.02) 0.33
HDLC (mmol/L)c 1.39 ± 0.37 1.40 ± 0.38 1.39 ± 0.36 0.001 (0.007) 0.85
Triglycerides (mmol/L)c 1.35 ± 0.73 1.32 ± 0.71 1.37 ± 0.90 0.002 (0.015) 0.48
hsCRPc 0.26 ± 0.43 0.24 ± 0.39 0.27 ± 0.48 0.003 (0.009) 0.67
Total energy intake (kcal/day) 2280 ± 652 2274 ± 653 2276 ± 653 −3.90 (5.26) 0.46
Vegetables (g/day) 180 ± 98 182 ± 100 180 ± 99 −0.18 (0.90) 0.85
Fruits (g/day) 196 ± 127 193 ± 125 197 ± 127 0.29 (1.14) 0.80
Wine (g/day) 41.2 ± 58.2 42.8 ± 70.0 42.5 ± 60.6 0.70 (0.55) 0.20
Alcohol (g/day) 10.6 ± 12.3 10.9 ± 12.7 10.8 ± 12.8 0.13 (0.11) 0.22
  1. Data represented as mean ± standard deviation.
  2. aMultivariable Cox proportional hazards model for incidence of cardiovascular disease (CVD) during follow-up adjusting for age and sex with HR referring to hazard ratio per risk G allele using an additive genetic model.
  3. bLinear regression analyses of rs4977574 G allele using an additive genetic model with quantitative traits or characteristics at baseline adjusting for age and sex when appropriate with β referring to associated effect estimate per risk G allele.
  4. cIn MDC-CC only, N = 4,828 (AA N = 1,460; AG N = 2,381; GG N = 987).
  5. CI, Confidence Interval; CVD, cardiovascular disease; SE, standard error; BMI, Body Mass Index; SBP, Systolic Blood Pressure; DBP, Diastolic Blood Pressure; FPG, Fasting Plasma Glucose; HbA1C, Hemoglobin A1C; LDLC, Low-Density Lipoprotein Cholesterol; HDLC, High-Density Lipoprotein Cholesterol; hsCRP, High-Sensitivity C-Reactive Protein.