rs4977574 genotype | HR (95% CI) a | P trend | |||
---|---|---|---|---|---|
AA | AG | GG | or β (SE) b | ||
Total number | 7325 | 11777 | 4847 | ||
Sex (%women) | 62.6 | 62.3 | 62.3 | ||
Incident CVD N (%) | 863 (11.8) | 1562 (13.3) | 739 (15.3) | 1.16 (1.10-1.22) | 4 × 10−09 |
Age (years) | 57.9 ± 7.7 | 57.9 ± 7.6 | 57.8 ± 7.7 | −0.04 (0.07) | 0.60 |
BMI (kg/m2) | 25.7 ± 3.9 | 25.6 ± 3.9 | 25.7 ± 3.9 | 0.001 (0.035) | 0.98 |
Waist (cm) | 83.6 ± 15.6 | 83.4 ± 12.8 | 83.7 ± 16.7 | 0.02 (0.11) | 0.87 |
SBP (mmHg) | 141 ± 20 | 141 ± 20 | 141 ± 20 | 0.21 (0.17) | 0.21 |
DBP (mmHg) | 85 ± 10 | 85 ± 10 | 86 ± 10 | 0.03 (0.09) | 0.76 |
FPG (mmol/L)c | 5.63 ± 0.84 | 5.62 ± 0.72 | 5.66 ± 0.91 | 0.009 (0.016) | 0.59 |
HbA1C (mmol/mol)c | 39.6 ± 4.94 | 39.6 ± 4.82 | 39.9 ± 5.32 | 0.13 (0.10) | 0.19 |
LDLC (mmol/L)c | 4.15 ± 1.00 | 4.19 ± 0.98 | 4.19 ± 0.97 | 0.02 (0.02) | 0.33 |
HDLC (mmol/L)c | 1.39 ± 0.37 | 1.40 ± 0.38 | 1.39 ± 0.36 | 0.001 (0.007) | 0.85 |
Triglycerides (mmol/L)c | 1.35 ± 0.73 | 1.32 ± 0.71 | 1.37 ± 0.90 | 0.002 (0.015) | 0.48 |
hsCRPc | 0.26 ± 0.43 | 0.24 ± 0.39 | 0.27 ± 0.48 | 0.003 (0.009) | 0.67 |
Total energy intake (kcal/day) | 2280 ± 652 | 2274 ± 653 | 2276 ± 653 | −3.90 (5.26) | 0.46 |
Vegetables (g/day) | 180 ± 98 | 182 ± 100 | 180 ± 99 | −0.18 (0.90) | 0.85 |
Fruits (g/day) | 196 ± 127 | 193 ± 125 | 197 ± 127 | 0.29 (1.14) | 0.80 |
Wine (g/day) | 41.2 ± 58.2 | 42.8 ± 70.0 | 42.5 ± 60.6 | 0.70 (0.55) | 0.20 |
Alcohol (g/day) | 10.6 ± 12.3 | 10.9 ± 12.7 | 10.8 ± 12.8 | 0.13 (0.11) | 0.22 |