Table 3 Summary of the meta-analysis results for the associations between the selected variants and CRC risk

rs1342387

1871/2597

CC

1

1

CT

0.80 (0.70-0.92), 0.002

0.82 (0.67-1.00), 0.052

8.55/4

0.0733

53.2%

0.307

TT

0.71 (0.59- 0.86), < 0.001

0.71 (0.59- 0.86), < 0.001

3.28/4

0.5114

0%

0.351

CT + TT

0.77 (0.68- 0.89), < 0.001

0.79 (0.66- 0.95), 0.011

8.06/4

0.089

50.4%

0.209

rs266729

3635/4411

CC

1

1

CG

0.97 (0.79-1.19), 0.756

0.97 (0.77-1.22), 0.784

6.42/5

0.267

22.2%

0.253

GG

0.94 (0.84-1.05), 0.262

0.93 (0.78-1.10), 0.381

11.95/5

0.036

58.2%

0.288

CG + GG

0.95 (0.86-1.03), 0.221

0.93 (0.81-1.08), 0.354

14.45/6

0.025

58.5%

0.401

rs2241766

1519/2310

TT

1

1

TG

1.23 (1.08-1.40), 0.002

1.16 (0.92-1.46), 0.202

15.83/6

0.147

62.1%

0.120

GG

1.19 (0.92-1.53), 0.174

1.19 (0.91-1.56), 0.209

6.38/6

0.382

6.0%

0.670

TG + GG

1.22 (1.07-1.37), 0.002

1.18 (0.96-1.43), 0.108

12.93/6

0.044

53.6%

0.173

rs1501299

2749/4005

GG

1

1

TG

0.92 (0.82-1.02), 0.088

0.95 (0.82-1.05), 0.133

11.34/9

0.253

20.6%

0.083

TT

0.97 (0.81-1.18), 0.946

0.97 (0.81-1.18), 0.782

7.11/8

0.524

0%

0.530

TG + TT

0.92 (0.84-1.02), 0.131

0.93 (0.83-1.04), 0.205

10.49/9

0.312

14.2%

0.086

rs822395

1901/2639

AA

1

1

AC

1.01 (0.88-1.16), 0.898

1.00 (0.86-1.18), 0.963

5.38/4

0.250

25.7%

0.498

CC

0.92 (0.72-1.17), 0.497

0.92 (0.72-1.17), 0.502

3.04/4

0.551

0%

0.032

AC + CC

0.99 (0.87-1.13), 0.927

0.99 (0.87-1.13), 0.930

3.83/4

0.429

0%

0.793

rs12733285

1401/2139

CC

1

1

CT

0.86 (0.72-1.03), 0.092

0.86 (0.65-1.13), 0.277

6.81/3

0.0782

56.0%

0.841

TT

0.96 (0.69-1.33), 0.786

0.96 (0.69-1.33), 0.795

1.45/2

0.485

0%

0.958

CT + TT

0.87 (0.74-1.04), 0.108

0.87 (0.66-1.14), 0.304

7.12/3

0.068

57.8%

0.813