From: Protective variant associated with alcohol dependence in a Mexican American cohort
dbSNP RS ID (rs991316) | AlcDepClust | AlcDep3 | AlcDep4 |
---|---|---|---|
Association analysis with no covariates | Â | Â | Â |
Beta +/− StdError | −0.8029 +/− 0.2065 | −0.5853 +/− 0.1376 | −0.4533 +/− 0.1097 |
T-stat | −3.8870 | −4.2550 | −4.1320 |
P-value | 1.013E-04 | 2.58E-05 | 4.34E-05 |
Association following winsorization | Â | Â | Â |
Beta +/− StdError | −0.8029 +/− 0.2065 | −0.5566 +/− 0.1288 | −0.4345 +/− 0.1023 |
T-stat | −3.8870 | −4.322 | −4.248 |
P-value | 1.013E-04 | 1.93E-05 | 2.65E-05 |
Permutation testing | Â | Â | Â |
Number of permutations performed | 630,000 | 1,000,000 | 1,000,000 |
Empirical adaptive P-value | 6.35E-05 | 3.00E-05 | 3.80E-05 |
Association analysis with covars | Â | Â | Â |
(Unscaled Beta, P-value) | Â | Â | Â |
Additive | −0.8279, 9.869E-05 | −0.5886, 1.571E-05 | −0.4543, 3.189E-05 |
Sex | −0.9037, 6.869E-04 | −0.7048, 2.748E-04 | −0.5195, 8.147E-04 |
Age | 0.02708, 0.4354 | 0.06998, 4.863E-03 | 0.04654, 0.01935 |
(Scaled Beta, P-value) | Â | Â | Â |
Additive |  | −0.2035, 1.571E-05 | −0.1971, 3.189E-05 |
Sex |  | −0.1707, 2.748E-04 | −0.1579, 8.147E-04 |
Age | Â | 0.1318, 4.863E-03 | 0.1100, 0.01935 |