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Table 2 rs991316 association analysis

From: Protective variant associated with alcohol dependence in a Mexican American cohort

dbSNP RS ID (rs991316)

AlcDepClust

AlcDep3

AlcDep4

Association analysis with no covariates

   

Beta +/− StdError

−0.8029 +/− 0.2065

−0.5853 +/− 0.1376

−0.4533 +/− 0.1097

T-stat

−3.8870

−4.2550

−4.1320

P-value

1.013E-04

2.58E-05

4.34E-05

Association following winsorization

   

Beta +/− StdError

−0.8029 +/− 0.2065

−0.5566 +/− 0.1288

−0.4345 +/− 0.1023

T-stat

−3.8870

−4.322

−4.248

P-value

1.013E-04

1.93E-05

2.65E-05

Permutation testing

   

Number of permutations performed

630,000

1,000,000

1,000,000

Empirical adaptive P-value

6.35E-05

3.00E-05

3.80E-05

Association analysis with covars

   

(Unscaled Beta, P-value)

   

Additive

−0.8279, 9.869E-05

−0.5886, 1.571E-05

−0.4543, 3.189E-05

Sex

−0.9037, 6.869E-04

−0.7048, 2.748E-04

−0.5195, 8.147E-04

Age

0.02708, 0.4354

0.06998, 4.863E-03

0.04654, 0.01935

(Scaled Beta, P-value)

   

Additive

 

−0.2035, 1.571E-05

−0.1971, 3.189E-05

Sex

 

−0.1707, 2.748E-04

−0.1579, 8.147E-04

Age

 

0.1318, 4.863E-03

0.1100, 0.01935