Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson’s disease – a multicenter study

BMC Medical Genetics

Table 5 Individual SNP associations with risk of PD

		Sweden PD-Goth	Italy	Sweden PD-Link	Malta	Poland	Germany	Meta-analysis ²
SNP ¹	Genotype	OR/allele (CI)	OR/allele (CI)	OR/allele (CI)	OR/allele (CI)	OR/allele (CI)	OR/allele (CI)	OR/allele (CI)	p-value
2 – rs7557529	G > A	0.9 (0.7 – 1.2)	0.8 (0.7 – 1.0)	1.2 (1.0 – 1.6)	1.5 (1.1 – 2.0)	1.3 (1.0 – 1.8)	1.0 (0.6 – 1.7)	1.08 (0.96 – 1.21)	0.18
P1 – rs35652124	A > G	0.8 (0.6 – 1.2)	0.7 (0.6 – 0.9)	1.3 (1.0 – 1.7)	0.9 (0.6 – 1.3)	1.3 (1.0 – 1.8)	1.1 (0.6 – 1.8)	0.99 (0.87 – 1.12)	0.86
P2 – rs6706649	G > A	0.9 (0.6 – 1.4)	1.3 (0.9 – 1.8)	1.1 (0.7 – 1.5)	1.6 (1.0 – 2.4)	1.0 (0.7 – 1.5)	0.9 (0.4 – 2.0)	1.14 (0.96 – 1.35)	0.14
P3 – rs6721961	C > A	1.8 (1.1 – 3.0)	1.1 (0.8 – 1.5)	0.9 (0.6 – 1.4)	0.7 (0.4 – 1.1)	1.0 (0.7 – 1.6)	1.3 (0.7 – 2.6)	1.07 (0.90 – 1.27)	0.45
3 – rs2886161	A > G	0.8 (0.6 – 1.2)	0.7 (0.5 – 0.9)	1.3 (1.0 – 1.7)	1.0 (0.7 – 1.4)	1.3 (1.0 – 1.8)	1.1 (0.6 – 1.8)	0.98 (0.87 – 1.12)	0.81
4 – rs1806649	G > A	1.0 (0.7 – 1.3)	1.2 (0.9 – 1.5)	0.8 (0.6 – 1.1)	0.8 (0.6 – 1.2)	0.7 (0.5 – 0.9)	0.7 (0.4 – 1.2)	0.88 (0.77 – 1.01)	0.07
5 – rs2001350	A > G	2.0 (1.1 – 3.6)	1.3 (1.0 – 1.8)	0.9 (0.6 – 1.3)	0.8 (0.4 – 1.4)	0.9 (0.6 – 1.4)	1.0 (0.5 – 2.1)	1.10 (0.91 – 1.34)	0.31
6 – 10183914	G > A	0.8 (0.6 – 1.2)	1.1 (0.9 – 1.4)	0.8 (0.6 – 1.1)	1.0 (0.7 – 1.4)	0.8 (0.6 – 1.1)	0.9 (0.6 – 1.6)	0.93 (0.82 – 1.05)	0.22

Odds ratios (OR) are given for the minor allele and presented as absolute numbers (95% CI). Sex was used as covariate for all materials except for Poland, where the number of males and females are identical in patients and controls.
¹For SNP locations see Figure 1 and Table 2.
²The meta-analysis was calculated using inverse-variance weighting of effects with two-sided p-values, including all six materials.

ISSN: 1471-2350