Table 4 Replication of haplotype associations with AAO of PD
From: Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson’s disease – a multicenter study
Sweden PD-Goth | Italy | Sweden PD-Link | Malta | Poland | Germany | Meta-analysis 2 | |||
|---|---|---|---|---|---|---|---|---|---|
SNP 1 | Haplotypes | Years/allele (CI) | Years/allele (CI) | Years/allele (CI) | Years/allele (CI) | Years/allele (CI) | Years/allele (CI) | Years/allele (CI) | p-value |
2, 3, 4, 5, 6 | GAAAA | +4.1 (+1.3 – +6.8) | +0.6 (−1.5 – +2.6) | +2.8 (+0.5 – +5.1) | −0.4 (−5.0 – +4.3) | +1.2 (−1.6 – +4.0) | −0.2 (−6.8 – +6.5) | +1.28 (−0.01 – +2.54) | 0.024 |
GAGGG | −0.9 (−4.6 – +32.8) | −0.4 (−2.9 – +2.2) | +2.1 (−1.6 – +6.0) | +0.5 (−7.0 – +8.1) | −0.7 (−4.2 – +2.8) | +1.3 (−5.4 – +8.0) | +0.19 (−1.50 – +1.89) | 0.59 | |
GAAAG | −3.6 (−9.1 – +2.0) | −0.2 (−5.7 – +5.4) | +1.0 (−8.7 – +10.7) | +253.1 (−483.1 – +989.3) | −1.2 (−10.8 – +8.4) | −60.9 (−221.2 – +99.3) | −0.16 (−4.46 – +4.14) | 0.47 | |
P1, P2, P3 | AGC | +1.4 (−0.7 – +3.6) | +0.8 (−0.8 – +2.4) | −0.1 (−2.1 – +1.9) | +0.3 (−3.1 – +3.7) | −0.0 (−2.2 – +2.1) | −1.6 (−6.2 – +2.9) | +0.22 (−0.79 – +1.23) | 0.33 |
2, P1, P2, P3, 3, 4, 5, 6 | GAGCAAAA | +3.8 (+1.1 – +6.5) | +0.7 (−1.4 – +2.7) | +2.6 (+0.3 – +5.0) | −0.4 (−5.0 – +4.3) | +0.4 (−2.8 – +3.6) | −0.7 (−7.2 – +5.7) | +1.10 (−0.20 – +2.40) | 0.048 |
GAGAAGGG | −0.8 (−4.6 – +2.9) | −0.3 (−2.9 – +2.2) | +2.1 (−1.7 – +6.0) | −0.5 (−7.0 – +8.0) | +0.5 (−3.7 – +4.8) | +1.3 (−5.4 – +8.0) | +0.51 (−1.26 – +2.28) | 0.71 | |
GAGCAAAG | −3.0 (−8.6 – +2.6) | +0.2 (−5.4 – +5.8) | +0.8 (−9.1 – +10.6) | −2817.1 (−5873.3 – +239.1) | −0.6 (−11.4 – +10.2) | −134.6 (−321.2 – +51.9) | +0.09 (−4.35 – +4.52) | 0.52 |