From: Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson’s disease – a multicenter study
Sweden PD-Goth | Italy | Sweden PD-Link | Malta | Poland | Germany | Meta-analysis 2 | |||
---|---|---|---|---|---|---|---|---|---|
SNP 1 | Haplotypes | OR/allele (CI) | OR/allele (CI) | OR/allele (CI) | OR/allele (CI) | OR/allele (CI) | OR/allele (CI) | OR/allele (CI) | p-value |
2, 3, 4, 5, 6 | GAAAA | 0.8 (0.5 – 1.1) | 1.1 (0.9 – 1.5) | 0.9 (0.7 – 1.2) | 0.8 (0.6 – 1.3) | 0.7 (0.5 – 0.9) | 0.7 (0.4 – 1.3) | 0.88 (0.76 – 1.03) | 0.052 |
GAGGG | 2.1 (1.2 – 3.8) | 1.2 (0.8 – 1.7) | 0.9 (0.5 – 1.3) | 0.7 (0.4 – 1.3) | 1.0 (0.6 – 1.6) | 1.1 (0.5 – 2.5) | 1.00 (0.81 – 1.24) | 0.50 | |
GAAAG | 2.8 (1.0 – 7.7) | 2.8 (1.1 – 6.8) | 0.4 (0.1 – 1.2) | 0.0 (0.0 – 2.9 × 1018) | 0.5 (0.2 – 1.7) | 0.0 (0.0 – 21.6) | 0.98 (0.54 – 1.77) | 0.53 | |
P1, P2, P3 | AGC | 1.0 (0.7 – 1.3) | 1.1 (0.9 – 1.3) | 0.8 (0.6 – 1.1) | 1.0 (0.7 – 1.3) | 0.8 (0.6 – 1.0) | 0.9 (0.5 – 1.5) | 0.92 (0.81 – 1.04) | 0.09 |
2, P1, P2, P3, 3, 4, 5, 6 | GAGCAAAA | 0.8 (0.6 – 1.1) | 1.1 (0.9 – 1.5) | 0.9 (0.7 – 1.2) | 0.8 (0.6 – 1.3) | 0.5 (0.3 – 0.7) | 0.7 (0.4 – 1.3) | 0.84 (0.72 – 0.98) | 0.012 |
GAGAAGGG | 2.4 (1.3 – 4.5) | 1.2 (0.9 – 1.8) | 0.9 (0.6 – 1.4) | 0.8 (0.4 – 1.4) | 0.6 (0.3 – 1.0) | 1.1 (0.5 – 2.5) | 0.95 (0.76 – 1.18) | 0.68 | |
GAGCAAAG | 2.9 (1.0 – 8.4) | 2.8 (1.1 – 6.8) | 0.4 (0.1 – 1.2) | 0.0 (0.0 – 3.3 × 1036) | 0.4 (0.1 – 1.5) | 0.0 (0.0 – 29.2) | 0.95 (0.52 – 1.72) | 0.57 |