From: Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson’s disease – a multicenter study
Parameter | Sweden PD-Goth 1 | Italy | Sweden PD-Link | ||||||
---|---|---|---|---|---|---|---|---|---|
PD | Control | p-value | PD | Control | p-value | PD | Control | p-value | |
N | 165 | 190 | --- | 329 | 450 | --- | 195 | 379 | --- |
Sex (Male) | 94 (57.0) | 70 (36.8) | <0.001 | 205 (62.3) | 179 (39.8) | <0.001 | 121 (62.1) | 187 (49.3) | 0.0043 |
AAS (years) | 68.2 ± 8.8 | 69.1 ± 9.3 | 0.698 | 66.5 ± 9.2 | 57.0 ± 17.4 | <0.001 | 71.4 ± 8.7 | 67.5 ± 9.7 | <0.0013 |
AAO2 (years) | 59.0 ± 10.2 | --- | --- | 60.1 ± 10.1 | --- | --- | 63.6 ± 10.0 | --- | --- |
N = 164 | N = 328 | ||||||||
FH | 15 (9.3) | 9 (4.8) | 0.096 | 24 (7.3) | ni | ni | 14 (7.2) | 15 (4.0) | 0.095 |
N = 162 | N = 189 | ||||||||
Current smoker | 9 (8.7) | 13 (8.3) | 0.897 | 17 (8.2) | ni | ni | 9 (4.6) | 56 (14.8) | <0.001 |
N = 208 | N = 194 | ||||||||
Ever smoked | 38 (36.9) | 81 (51.6) | 0.020 | 77 (37.0) | ni | ni | 63 (32.5) | 183 (48.3) | <0.001 |
N = 208 | N = 194 | ||||||||
Parameter | Malta | Poland | Germany | ||||||
PD | Control | p-value | PD | Control | p-value | PD | Control | p-value | |
N | 101 | 313 | --- | 192 | 192 | --- | 56 | 76 | --- |
Sex (Male) | 63 (62.4) | 197 (62.9) | 0.9193 | 117 (60.9) | 117 (60.9) | 1.0003 | 33 (58.9) | 34 (44.7) | 0.1073 |
AAS (years) | 71.3 ± 10.0 | 72.7 ± 10.0 | 0.1763 | 63.7 ± 10.9 | 72.9 ± 9.9 | <0.0014 | 66.0 ± 11.9 | 57.8 ± 10.8 | <0.0013 |
AAO1 (years) | 64.1 ± 11.6 | --- | --- | 55.2 ± 10.9 | --- | --- | 58.7 ± 12.5 | --- | --- |
N = 76 | N = 54 | ||||||||
FH | 13 (12.9) | 8 (2.6) | <0.001 | ni | ni | ni | ni | ni | ni |
Current smoker | 3 (3.0) | 25 (8.1) | 0.076 | ni | ni | ni | ni | ni | ni |
N = 308 | |||||||||
Ever smoked | 31 (30.7) | 149 (47.6) | 0.003 | ni | ni | ni | ni | ni | ni |