TY - JOUR AU - von Otter, Malin AU - Bergström, Petra AU - Quattrone, Aldo AU - De Marco, Elvira Valeria AU - Annesi, Grazia AU - Söderkvist, Peter AU - Wettinger, Stephanie Bezzina AU - Drozdzik, Marek AU - Bialecka, Monika AU - Nissbrandt, Hans AU - Klein, Christine AU - Nilsson, Michael AU - Hammarsten, Ola AU - Nilsson, Staffan AU - Zetterberg, Henrik PY - 2014 DA - 2014/12/12 TI - Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson’s disease – a multicenter study JO - BMC Medical Genetics SP - 131 VL - 15 IS - 1 AB - The transcription factor Nrf2, encoded by the NFE2L2 gene, is an important regulator of the cellular protection against oxidative stress. Parkinson’s disease is a neurodegenerative disease highly associated with oxidative stress. In a previously published study, we reported associations of NFE2L2 haplotypes with risk and age at onset of idiopathic Parkinson’s disease in a Swedish discovery material and a Polish replication material. Here, we have extended the replication study and performed meta-analyses including the Polish material and four new independent European patient-control materials. Furthermore, all SNPs included in the haplotype windows were investigated individually for associations with Parkinson’s disease in meta-analyses including all six materials. SN - 1471-2350 UR - https://doi.org/10.1186/s12881-014-0131-4 DO - 10.1186/s12881-014-0131-4 ID - von Otter2014 ER -