Table 1 Characteristics of studies included in the meta-analysis
| Â | First Author | Year | Country | Ethnicity | Cancer type | HWE of control | No. (case/control) | Genotypic frequencies of cases (n, (%)) | Allele frequencies of cases (n, (%)) | Genotypic frequencies of controls (n, (%)) | Allele frequencies of controls (n, (%)) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Â | Â | Â | Â | Â | TT | TC | CC | T | C | TT | TC | CC | T | C |
1 | Hu | 2009 | China | Asian | Breast cancer | 0.057 | 1009/1093 | 707 (70) | 258 (25.6) | 44 (4.4) | 1672 (82.9) | 346 (17.1) | 816 (74.7) | 248 (22.7) | 29 (2.6) | 1880 (86) | 306 (14) |
2 | Tian | 2009 | China | Asian | Lung cancer | 0.404 | 1058/1035 | 781 (73.8) | 253 (23.9) | 24 (2.3) | 1815 (85.8) | 301 (14.2) | 755 (73.0) | 254 (24.5) | 26 (2.5) | 1764 (85.2) | 306 (14.8) |
3 | Catucci | 2010 | Italy; Germany | Caucasian | Breast cancer | 0.284 | 1579/2167 | 950 (60.16) | 545 (34.52) | 84 (5.32) | 2445 (77.4) | 713 (22.6) | 1305 (60.22) | 742 (34.24) | 120 (5.54) | 3352 (77.3) | 982 (22.7) |
4 | Liu | 2010 | US | Caucasian | Squamous cell carcinoma of the head and neck | 0.441 | 1109/1130 | 745 (67.2) | 309 (27.9) | 55 (4.9) | 1799 (81.1) | 419 (18.9) | 710 (62.8) | 366 (32.4) | 54 (4.8) | 1786 (79) | 474 (21) |
5 | Srivastava | 2010 | India | Asian | Gallbladder cancer | 0.566 | 230/230 | 112 (48.7) | 97 (42.2) | 21 (9.1) | 321 (69.8) | 139 (30.2) | 121 (52.6) | 94 (40.9) | 15 (6.5) | 336 (73) | 124 (27) |
6 | Okubo | 2010 | Japan | Asian | Gastric cancer | 0.048 | 697/552 | 364 (65.9) | 151 (27.4) | 37 (6.7) | 879 (79.6) | 225 (20.4) | 466 (66.9) | 198 (28.4) | 33 (4.7) | 1130 (81.1) | 264 (18.9) |
7 | Akkiz | 2011 | Turkish | Asian | Hepatocellular carcinoma | 0.036 | 222/222 | 45 (20.3) | 87 (39.2) | 90 (40.5) | 177 (40) | 267 (60) | 47 (21.2) | 93 (41.9) | 82 (36.9) | 187 (42.1) | 257 (57.9) |
8 | George | 2011 | India | Asian | Prostate cancer | 0.073 | 159/230 | 48 (30.2) | 98 (61.6) | 13 (8.2) | 194 (61) | 124 (39) | 104 (45.2) | 92 (40.0) | 34 (14.8) | 300 (65.2) | 160 (34.8) |
9 | Min | 2011 | Korea | Asian | Colorectal cancer | 0.453 | 446/502 | 292 (65.5) | 142 (31.8) | 12 (2.7) | 726 (81.4) | 166 (18.6) | 334 (66.5) | 154 (30.7) | 14 (2.8) | 822 (81.9) | 182 (18.1) |
10 | Mittal | 2011 | India | Asian | Bladder cancer | 0.029 | 212/250 | 95 (44.8) | 92 (43.4) | 25 (11.8) | 282 (66.5) | 142 (33.5) | 121 (48.4) | 94 (37.6) | 35 (14.0) | 336 (67.2) | 164 (32.8) |
11 | Vinci | 2011 | Italy | Caucasian | Lung cancer | 0.503 | 101/129 | 53 (52.5) | 41 (40.6) | 7 (6.9) | 147 (72.8) | 55 (27.2) | 70 (54.2) | 48 (37.2) | 11 (8.6) | 188 (72.9) | 70 (27.1) |
12 | Zhou | 2011 | China | Asian | Cervical squamous cell carcinoma | 0.005 | 226/309 | 134 (59.3) | 84 (37.2) | 8 (3.5) | 352 (77.9) | 100 (22.1) | 223 (68.2) | 71 (23.0) | 15 (4.8) | 517 (83.7) | 101 (16.3) |
13 | Alshatwi | 2012 | Saudi | Asian | Breast cancer | 0.304 | 92/89 | 27 (29.3) | 57 (62) | 8 (8.7) | 111 (60.3) | 73 (39.7) | 40 (45) | 36 (40.4) | 13 (14.6) | 116 (65.2) | 62 (34.8) |
14 | Kim | 2012 | Korea | Asian | Hepatocellular carcinoma | 0.278 | 159/201 | 109 (68.6) | 47 (29.5) | 3 (1.9) | 265 (83.3) | 53 (16.7) | 120 (59.7) | 74 (36.8) | 7 (35) | 314 (78.1) | 88 (21.9) |
15 | Umar | 2012 | India | Asian | Esophageal cancer | 0.087 | 289/309 | 155 (53.6) | 122 (42.2) | 12 (4.2) | 432 (74.7) | 146 (25.3) | 149 (48.2) | 140 (45.3) | 20 (6.5) | 438 (70.9) | 180 (29.1) |
16 | Xiang | 2012 | China | Asian | Hepatocellular carcinoma | 0.284 | 100/100 | 36 (36) | 40 (40) | 24 (24) | 112 (56) | 88 (44) | 54 (54) | 36 (36) | 10 (10) | 144 (72) | 56 (28) |
17 | Zhou | 2012 | China | Asian | Hepatocellular carcinoma | 0.1 | 186/483 | 141 (75.8) | 41 (22.0) | 4 (2.2) | 323 (86.8) | 49 (13.2) | 371 (76.8) | 100 (20.7) | 12 (2.48) | 842 (87.2) | 124 (12.8) |
18 | Ahn | 2012 | Korea | Asian | Gastric cancer | 0.829 | 461/477 | 323 (70.1) | 123 (26.7) | 15 (3.3) | 769 (83.4) | 153 (16.6) | 299 (66.9) | 134 (30.0) | 14 (3.1) | 732 (81.9) | 162 (18.1) |
19 | Hasani | 2013 | Iran | Asian | Childhood acute lymphoblastic leukemia | 0.249 | 75/115 | 35 (46.7) | 28 (37.3) | 12 (16.0) | 98 (65.3) | 52 (34.7) | 61 (53.0) | 42 (36.5) | 12 (10.4) | 164 (71.3) | 66 (28.7) |
20 | Wei | 2013 | China | Asian | Esophageal cancer | 0.036 | 380/380 | 291 (81.3) | 60 (16.8) | 7 (2.0) | 642 (89.7) | 74 (10.3) | 289 (76.9) | 76 (20.2) | 11 (2.9) | 654 (87) | 98 (13) |
21 | Zou | 2013 | China | Asian | Hepatocellular carcinoma | 0.005 | 185/185 | 136 (73.5) | 44 (23.8) | 5 (2.7) | 316 (85.4) | 54 (14.6) | 123 (66.5) | 48 (25.9) | 14 (7.6) | 294 (79.5) | 76 (20.5) |
22 | Lv | 2013 | China | Asian | Colorectal cancer | 0.082 | 346/504 | 258 (74.6) | 86 (24.6) | 2 (5.8) | 602 (87) | 90 (13) | 366 (72.6) | 121 (24.0) | 17 (3.4) | 853 (84.6) | 155 (15.4) |
23 | Hu | 2013 | China | Asian | Colorectal cancer | 0.162 | 276/373 | 157 (74.4) | 49 (23.2) | 5 (2.4) | 363 (86) | 59 (14) | 282 (75.6) | 81 (21.7) | 10 (2.7) | 645 (86.5) | 101 (13.5) |
24 | Shan | 2013 | China | Asian | Hepatocellular carcinoma | 0.005 | 172/185 | 128 (74.4) | 37 (21.5) | 7 (4.1) | 293 (85.2) | 51 (14.8) | 123 (66.7) | 48 (25.8) | 14 (7.5) | 294 (79.5) | 76 (20.5) |
25 | Wu | 2013 | China | Asian | Gastric cancer | 0.854 | 200/211 | 149 (74.5) | 47 (23.5) | 4 (2.0) | 345 (86.3) | 55 (13.7) | 166 (78.7) | 42 (19.9) | 3 (1.4) | 374 (88.6) | 48 (11.4) |
26 | Omrani | 2014 | Iran | Asian | Breast cancer | <0.001 | 236/203 | 131 (55.5) | 44 (18.6) | 61 (25.8) | 306 (64.8) | 166 (35.2) | 130 (64.0) | 48 (23.7) | 25 (12.3) | 308 (75.8) | 98 (24.2) |
27 | Du | 2014 | China | Asian | Renal cell cancer | 0.594 | 354/362 | 251 (70.9) | 94 (26.6) | 9 (2.5) | 596 (84.2) | 112 (15.8) | 255 (70.4) | 96 (26.5) | 11 (3.1) | 606 (83.7) | 118 (16.3) |
28 | Huo | 2014 | China | Asian | Oral squamous cell carcinoma | 0.419 | 872/667 | 616 (70.6) | 243 (27.9) | 13 (1.5) | 1475 (84.6) | 269 (15.4) | 505 (75.7) | 148 (22.2) | 14 (2.1) | 1158 (86.8) | 176 (13.2) |
29 | Ma | 2014 | China | Asian | Hepatocellular carcinoma | <0.001 | 984/969 | 724 (73.6) | 241 (24.5) | 19 (1.9) | 1689 (85.8) | 279 (14.2) | 765 (79.0) | 179 (18.4) | 25 (2.6) | 1709 (88.2) | 229 (11.8) |
30 | Pu | 2014 | China | Asian | Gastric cancer | 0.082 | 196/504 | 141 (71.9) | 50 (25.5) | 5 (2.6) | 332 (84.7) | 60 (15.3) | 366 (72.6) | 121 (24.0) | 17 (3.4) | 853 (84.6) | 155 (15.4) |
31 | Chu | 2014 | China | Asian | Hepatocellular carcinoma | 0.321 | 188/337 | 119 (63.30) | 60 (31.91) | 9 (4.79) | 298 (79.3) | 78 (20.7) | 281 (83.38) | 55 (16.32) | 1 (0.30) | 617 (91.5) | 57 (8.5) |