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Table 7 Results of the QTDT analyses for the rs10507337 C allele in relation to Doppler diastolic indexes and composite score

From: Left ventricular diastolic function associated with common genetic variation in ATP12Ain a general population

 

Parameter estimate

χ2

P

LV diastolic indexes

   

Transmitral E peak (cm/s)

1.40

0.22

0.64

Transmitral A peak (cm/s)

-3.30

1.59

0.21

Transmitral E/A ratio

0.17

6.61

0.010

TDI e' peak (cm/s)

1.19

8.61

0.003

TDI a' peak (cm/s)

-0.25

0.21

0.65

TDI e'/a' ratio

0.26

9.13

0.003

E/e' ratio

-0.33

0.74

0.39

Composite diastolic score

0.62

9.04

0.003

  1. The orthogonal model accounted for between- and within-family variability components. The parameter estimate for the within-family component of the rs10507337 C allele indicates the direction and size of the association. Analyses were adjusted for center, sex, age, body mass index, heart rate and diastolic blood pressure. TDI, Tissue Doppler Imaging.