Table 6 Adjusted Doppler diastolic indexes and composite score by CCTTC haplotype in all centers combined

Transmitral E peak (cm/s)

71.0 ± 1.75

72.3 ± 2.15

0.33

Transmitral A peak (cm/s)

60.7 ± 1.50

59.5 ± 1.83

0.26

Transmitral E/A ratio

1.27 ± 0.016

1.34 ± 0.031

0.009

TDI e' peak (cm/s)

10.7 ± 0.25

11.3 ± 0.30

0.0006

TDI a' peak (cm/s)

9.65 ± 0.24

9.53 ± 0.28

0.42

e'/a' ratio

1.23 ± 0.028

1.33 ± 0.045

0.008

E/e' ratio

7.15 ± 0.11

6.97 ± 0.19

0.29

Composite diastolic score

-0.039 ± 0.036

0.27 ± 0.092

0.001