Table 4 Adjusted Doppler diastolic indexes and composite score by rs10507337 by country and all centers combined

Belgium (n = 777)

TT (n = 663)

75.2 ± 0.58

65.3 ± 0.51

1.25 ± 0.013

11.3 ± 0.092

10.2 ± 0.084

1.23 ± 0.018

7.13 ± 0.064

-0.097 ± 0.046

C allele carriers (n = 114)

76.9 ± 1.32

62.9 ± 1.12

1.34 ± 0.028

12.2 ± 0.19

9.99 ± 0.16

1.38 ± 0.038

6.87 ± 0.16

0.35 ± 0.094

P

0.22

0.044

0.0008

8.2×10^-6

0.15

0.0002

0.12

3.5†10^-6

Italy (n = 109)

TT (n = 101)

67.7 ± 1.68

59.3 ± 1.32

1.27 ± 0.030

10.3 ± 0.19

10.2 ± 0.17

1.05 ± 0.035

7.11 ± 0.20

-0.30 ± 0.10

C allele carriers (n = 8)

81.2 ± 4.80

59.1 ± 4.74

1.38 ± 0.11

11.6 ± 0.62

9.87 ± 0.58

1.18 ± 0.11

7.30 ± 0.66

0.26 ± 0.34

P

0.006

0.97

0.34

0.042

0.58

0.26

0.78

0.12

Poland (n = 143)

TT (n = 123)

74.4 ± 1.30

58.4 ± 1.06

1.36 ± 0.025

11.4 ± 0.20

9.13 ± 0.15

1.37 ± 0.030

7.05 ± 0.18

0.43 ± 0.087

C allele carriers (n = 20)

72.0 ± 3.31

58.0 ± 2.60

1.34 ± 0.066

10.8 ± 0.51

9.11 ± 0.38

1.24 ± 0.080

7.16 ± 0.43

0.17 ± 0.22

P

0.50

0.87

0.80

0.27

0.95

0.14

0.80

0.27

Russia (n = 137)

TT (n = 130)

65.6 ± 1.24

59.8 ± 1.03

1.20 ± 0.03

10.3 ± 0.19

9.45 ± 0.15

1.24 ± 0.044

6.96 ± 0.20

-0.14 ± 0.11

C allele carriers (n = 7)

61.8 ± 4.86

59.1 ± 3.92

1.22 ± 0.12

10.4 ± 0.69

9.74 ± 0.57

1.32 ± 0.16

6.20 ± 0.78

0.012 ± 0.38

P

0.45

0.86

0.84

0.93

0.61

0.62

0.34

0.70

All participants (n = 1166)

TT (n = 1017)

70.9 ± 1.74

60.8 ± 1.50

1.27 ± 0.016

10.68 ± 0.25

9.66 ± 0.24

1.22 ± 0.028

7.15 ± 0.11

-0.050 ± 0.036

C allele carriers (n = 149)

72.9 ± 2.06

59.4 ± 1.76

1.34 ± 0.028

11.36 ± 0.29

9.52 ± 0.27

1.33 ± 0.042

6.98 ± 0.18

0.28 ± 0.083

P

0.11

0.19

0.003

5.8×10^-5

0.32

0.003

0.28

0.0001

P*

/

/

0.014

0.0007

/

0.007

/

0.0008

P for heterogeneity

0.04

0.81

0.48

0.04

0.79

0.04

0.66

0.04