A study of genes encoding cytokines (IL6, IL10, TNF), cytokine receptors (IL6R, IL6ST), and glucocorticoid receptor (NR3C1) and susceptibility to bronchopulmonary dysplasia

Table 2 IL6 , IL6R , IL6ST , IL10 , and TNF minor allele frequencies in cases and controls in the northern Finnish and Canadian populations

		Northern Finland, n =253		Canada, n =126
Gene	Polymorphism¹	Case, control minor allele frequency	Pvalue	Case, control minor allele frequency	Pvalue
IL6	rs2069827	0.286, 0.265	0.6603	0.129, 0.119	0.8126
IL6	rs1800797	0.438, 0.454	0.7592	0.379, 0.388	0.8872
IL6	rs1800795	0.438, 0.454	0.7523	0.404, 0.404	0.9884
IL6	rs2069832	0.427, 0.457	0.5814	0.397, 0.404	0.8990
IL6	rs2069840	0.222, 0.237	0.7464	0.276, 0.243	0.5480
IL6R	rs4845617	0.400, 0.426	0.6304	0.276, 0.390	0.0568
IL6R	rs1386821	0.214, 0.203	0.795	0.172, 0.213	0.4144
IL6R	rs4075015	0.444, 0.423	0.6859	0.509, 0.462	0.4614
IL6R	rs4601580	0.417, 0.460	0.4527	0.491, 0.500	0.8898
IL6R	rs4553185	0.368, 0.434	0.2218	0.474, 0.463	0.8627
IL6R	rs4453032	0.273, 0.320	0.3479	0.431, 0.449	0.7804
IL6R	rs4845374	0.116, 0.121	0.8845	0.103, 0.096	0.8352
IL6R	rs4240872	0.389, 0.386	0.9567	0.293, 0.257	0.5259
IL6R	rs4072391	0.343, 0.361	0.7265	0.216, 0.184	0.5295
IL6ST	rs10471960	0.080, 0.104	0.4582	0.129, 0.125	0.9184
IL6ST	rs10940495	0.259, 0.303	0.3717	0.267, 0.239	0.6055
IL6ST	rs11739048	0.089, 0.105	0.6247	0.155, 0.140	0.7295
IL6ST	rs6875155	0.071, 0.103	0.3233	0.121, 0.125	0.9173
IL10	rs3024493	0.120, 0.153	0.3908	0.121, 0.191	0.1270
TNF	rs1799964	0.136, 0.155	0.6362	0.198, 0.169	0.5503
TNF	rs1800629	0.100, 0.144	0.2359	0.190, 0.132	0.2147

ISSN: 1471-2350