Association of cholesteryl ester transfer protein (CETP) gene polymorphism, high density lipoprotein cholesterol and risk of coronary artery disease: a meta-analysis using a Mendelian randomization approach

Wu, Zhijun; Lou, Yuqing; Qiu, Xiaochun; Liu, Yan; Lu, Lin; Chen, Qiujing; Jin, Wei

doi:10.1186/s12881-014-0118-1

Table 2 Summary estimates for ORs and 95% CI in different subgroups under various genetic contrasts

From: Association of cholesteryl ester transfer protein (CETP) gene polymorphism, high density lipoprotein cholesterol and risk of coronary artery disease: a meta-analysis using a Mendelian randomization approach

Genotype contrasts	Study population	Study number, (case/control), n(n/n)	P_{heterogeneity}	I², %	P value^a	OR	95% CI
Total studies
Allele comparison		45(23,713/26,824)	0.000	55.2	0.000	0.88	0.84-0.92
(B2 versus B1)
Dominant model		45(23,483/24,848)	0.000	48.6	0.000	0.85	0.79-0.91
(B1B2 + B2B2 versus B1B1)
Recessive model		45(23,460/24,880)	0.000	53.7	0.000	0.81	0.74-0.88
(B2B2 versus B1B2 + B1B1)
Homozygote comparison		44(23,364/24,742)	0.000	58.1	0.000	0.76	0.68-0.84
(B2B2 versus B1B1)
Studies comfirming to HWE
Allele comparison		38(13,326/20,048)	0.000	56.6	0.000	0.86	0.81-0.91
Dominant model		38(13,096/18,072)	0.002	45.1	0.000	0.82	0.76-0.89
Recessive model		38(13,073/18,104)	0.000	55.1	0.000	0.77	0.69-0.86
Homozygote comparison		37(12,977/17,966)	0.000	59.2	0.000	0.72	0.63-0.82
Subgroups analysis after excluding HWE-deviation studies
Ethnicity
Allele comparison	Asian	16(2,780/4,767)	0.000	67.7	0.002	0.77	0.66-0.90
	Caucasian	22(10,546/15,281)	0.222	18.0	0.000	0.91	0.87-0.95
Dominant model	Asian	16(2,550/2,791)	0.022	46.3	0.000	0.65	0.54-0.79
	Caucasian	22(10,546/15,281)	0.505	0	0.001	0.90	0.85-0.96
Recessive model	Asian	15(2,431/2,685)	0.000	66.7	0.008	0.66	0.49-0.90
	Caucasian	23(10,642/15,419)	0.106	27.9	0.000	0.84	0.76-0.92
Homozygote comparison	Asian	15(2,431/2,685)	0.000	66.6	0.000	0.54	0.38-0.76
	Caucasian	22(10,546/15,281)	0.159	23.2	0.000	0.82	0.74-0.90
Study design
Allele comparison	prospective	7(2,555/7,366)	0.116	41.3	0.061	0.92	0.84-1.00
	retrospective	31(10,771/12,682)	0.000	59.2	0.000	0.84	0.78-0.90
Dominant model	prospective	7(2,555/7,366)	0.161	35	0.081	0.89	0.79-1.01
	retrospective	31(10,518/10,738)	0.002	47.3	0.000	0.79	0.72-0.88
Recessive model	prospective	7(2,555/7,366)	0.219	27.4	0.119	0.89	0.76-1.03
	retrospective	31(10,518/10,738)	0.000	58.1	0.000	0.73	0.64-0.84
Homozygote comparison	prospective	7(2,555/7,366)	0.106	42.7	0.080	0.84	0.70-1.02
	retrospective	30(10,422/10,600)	0.000	61.6	0.000	0.67	0.57-0.79
Population source
Allele comparison	P-B	10(4,782/8,365)	0.308	14.7	0.015	0.93	0.88-0.99
	H-B	28(8,544/11,683)	0.000	60.6	0.000	0.82	0.75-0.89
Dominant model	P-B	10(4,782/8,365)	0.361	8.8	0.025	0.91	0.84-0.99
	H-B	28(8,314/9,707)	0.002	49.5	0.000	0.76	0.68-0.86
Recessive model	P-B	10(4,782/8,365)	0.568	0	0.055	0.91	0.82-1.00
	H-B	28(8,291/9,739)	0.000	59.1	0.000	0.70	0.59-0.82
Homozygote comparison	P-B	10(4,782/8,365)	0.292	16.4	0.020	0.86	0.76-0.98
	H-B	27(8,195/9,601)	0.000	62.7	0.000	0.63	0.52-0.77
Endpoint
Allele comparison	CAD	31(10,824/16,970)	0.000	62	0.000	0.85	0.79-0.91
	MI	5(2,029/2,787)	0.200	33.2	0.032	0.89	0.80-0.99
	ACS	2(473/291)	0.741	0	0.517	0.93	0.74-1.17
Dominant model	CAD	31(10,594/14,994)	0.001	49.5	0.000	0.81	0.73-0.89
	MI	5(2,029/2,787)	0.123	44.8	0.172	0.88	0.74-1.06
	ACS	2(473/291)	0.493	0	0.357	0.86	0.61-1.19
Recessive model	CAD	31(10,571/15,026)	0.000	62.8	0.000	0.75	0.66-0.87
	MI	5(2,029/2,787)	0.775	0	0.006	0.80	0.69-0.94
	ACS	2(473/291)	0.905	0	0.356	0.81	0.52-1.27
Homozygote comparison	CAD	30(10,475/14,888)	0.000	65.2	0.000	0.69	0.59-0.82
	MI	5(2,029/2,787)	0.300	17.9	0.008	0.76	0.63-0.93
	ACS	2(473/291)	0.723	0	0.273	0.76	0.46-1.24

^aTest for overall effect; P-B: population-based, H-B: hospital-based.

Back to article page

ISSN: 1471-2350

Contact us

General enquiries: ORSupport@springernature.com

BMC Medical Genetics

Contact us