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Table 1 The distribution of the Taq1B allele and genotype among CAD and controls, and P value of HWE in controls

From: Association of cholesteryl ester transfer protein (CETP) gene polymorphism, high density lipoprotein cholesterol and risk of coronary artery disease: a meta-analysis using a Mendelian randomization approach

 

Sample size

B1 allele, %

B2 allele, %

B1B1 genotype

B1B2 genotype

B2B2 genotype

HWE,

First author

Cases

Controls

Cases

Controls

Cases

Controls

Cases

Controls

Cases

Controls

Cases

Controls

P value

Arca M

415

403

60.4

58.1

39.6

41.9

153

134

187

184

68

71

0.57

Bhanushali AA

90

150

59.4

50.3

40.6

49.7

33

37

40

76

17

42

0.820

Blankenberg S

1214

574

60.8

57.2

39.3

42.8

407

175

644

303

149

93

0.047

Corella D

557

1180

62.4

63.6

37.6

36.4

224

482

247

537

86

161

0.557

Dedoussis GV

237

237

60.5

58.2

39.5

41.8

83

78

121

120

33

39

0.530

Durlach A

96

138

-a

-

-

-

-

-

-

-

13

39

-

Eiriksdottir G

388

794

59.1

52.6

40.9

47.4

128

194

191

396

59

155

0.072

Falchi A

100

100

58.5

56.0

41.5

44.0

30

30

57

52

13

18

0.581

Freeman DJ

498

1108

58.8

55.2

41.2

44.8

164

339

259

541

76

225

0.733

Fumeron F

608

724

60.0

59.5

40.0

40.5

209

258

312

346

87

120

0.826

Horne BD

3223

1588

57.5

56.0

42.5

44.0

1064

508

1579

762

580

318

0.293

Hsieh MC

101

264

42.1

29.7

57.9

70.3

19

23

47

111

35

130

0.920

Izar MC

386

604

40.1

43.0

59.9

57.0

32

66

238

374

107

145

0.000

Jensen MK [HPFS]

259

513

58.7

58.9

41.3

41.1

89

180

126

244

44

89

0.686

Jensen MK [NHS]

246

486

58.5

58.3

41.5

41.7

84

166

120

235

42

85

0.907

Kaestner S

204

35

53.9

60.0

46.1

40.0

53

13

114

16

37

6

0.778

Kawasaki I

24

361

79.2

53.6

20.8

46.4

15

101

8

185

1

75

0.565

Keavney B

4685

3460

57.7

56.9

42.3

43.1

1477

1100

2175

1527

790

646

0.005

Kolovou G

374

97

60.7

46.4

39.3

53.6

126

22

202

45

46

29

0.573

Li J

236

54

58.8

58.8

41.2

41.3

82

15

73

19

21

6

0.997

Liu S

384

384

58.1

56.9

41.9

43.1

125

122

196

193

63

69

0.628

McCaskie PA

556

2683

59.3

57.0

40.7

43.0

196

860

262

1328

93

485

0.482

Meiner V

577

659

57.1

52.6

42.9

47.4

173

166

282

320

95

134

0.383

Mohrschladt MF

116

184

56.9

54.9

43.1

45.1

36

57

60

88

20

39

0.642

Muendlein A

332

225

62.0

57.3

38.0

42.7

125

71

162

116

45

38

0.420

Padmaja N

504

338

58.5

49.3

41.5

50.7

163

86

264

161

77

91

0.386

Park KW

119

106

-

-

-

-

49

30

-

-

-

-

-

Poduri A

265

150

64.3

49.3

35.7

50.7

117

33

107

82

41

35

0.252

Porchay-Balderelli I

223

2901

63.9

59.5

36.1

40.5

95

1012

95

1431

33

458

0.198

Qin Q

249

167

58.8

58.4

41.2

41.6

81

49

131

97

37

21

0.012

Rahimi Z

207

92

62.3

50.0

37.7

50.0

57

20

144

52

6

20

0.211

Rejeb J

212

104

71.0

65.9

29.0

34.1

104

45

93

47

15

12

0.959

Schierer A

349

2082

47.0

49.0

53.0

51.0

-

-

-

-

-

-

-

Tenkanen H

72

226

54.2

55.5

45.8

44.5

19

64

40

123

13

39

0.125

Van Acker BA

792

539

59.4

58.1

40.6

41.9

275

171

391

284

126

84

0.06

Wang SH

111

75

58.6

56.0

41.4

44.0

38

22

54

41

19

12

0.327

Wang W

128

247

64.8

54.0

35.2

46.0

50

72

66

123

12

52

0.968

Whiting BM

3319

1385

58.1

56.7

41.9

43.3

792

280

1201

377

402

170

0.039

Wu JH

200

285

56.7

52.0

43.3

48.0

45

63

79

159

25

52

0.007

Yan SK

106

64

60.4

56.3

39.6

43.8

41

19

46

34

19

11

0.526

Yang J

83

163

62.7

52.1

37.3

47.9

31

47

42

76

10

40

0.401

Yilmaz H

173

111

59.0

55.5

41.0

44.5

66

39

72

46

35

26

0.093

Zhang GB

88

94

58.0

60.6

42.0

39.4

31

32

40

50

17

12

0.268

Zhang YX

334

301

67.7

65.1

32.3

34.9

174

136

104

120

56

45

0.034

Zhao SP

238

203

62.0

56.4

38.0

43.6

95

60

105

109

38

34

0.191

Zheng KQ

203

100

60.6

60.5

39.4

39.5

66

33

114

55

23

12

0.132

Zhou DF

47

330

57.4

68.0

42.6

32.0

17

157

20

135

10

38

0.280

Total

23928

27068

58.6

56.3

41.4

43.7

7533

7667

10910

11720

3634

4521

 
  1. HWE: Hardy-Weinberg equilibrium. The P value of HWE determined by the χ2 test or Fisher's exact test in control groups; a: No data.