Figure 3
From: Familial imbalance in 16p13.11 leads to a dosage compensation rearrangement in an unaffected carrier
Postzygotic hypothesis for the rearrangement in chromosome 16 leading to genomic compensation in the mother (II:3). Mitotic recombination between a paternal chromatid carrying the duplication and a normal maternal chromatid during the first zygotic divisions would originate four different chromatids, two of which would be selected in a compensated genotype. Circles indicate region 16p13.11, which is colored as in Figure 2. P and M designate the paternal and maternal chromosome, respectively.