Skip to main content

Table 3 Top single-nucleotide polymorphisms (SNPs) associated with lymphoma-specific death A (p random ≤ 10 -6 ) in the meta-analysis of FL patients in SCALE and UCSF (N = 586)

From: A comprehensive evaluation of the role of genetic variation in follicular lymphoma survival

      

SCALE

 

UCSF

 

Meta-analysis

 

Heterogeneity

   

Chr

SNP

Position

A1

A2

MAF

HR (95% CI)

pSCALE

HR (95% CI)

pUCSF

HR (95% CI)

pRANDOM

pHET

I2

Gene

Left gene

Right gene

17

rs10491178

64661568

A

G

0.06

3.10 (1.97; 4.89)

1.13E-06

3.50 (1.28; 9.53)

1.36E-02

3.17 (2.09; 4.79)

5.24E-08

0.83

0

ABCA10

ABCA6

LOC100133319

1

rs3131729

57971355

A

G

0.13

2.58 (1.77; 3.76)

9.24E-07

2.00 (0.92; 4.31)

7.58E-02

2.45 (1.75; 3.44)

2.22E-07

0.56

0

DAB1

C8B

LOC729423

4

rs11932201

14304530

C

A

0.17

2.10 (1.48; 2.97)

2.93E-05

2.50 (1.13; 5.55)

2.29E-02

2.16 (1.57; 2.97)

2.24E-06

0.69

0

NA

LOC152742

LOC441009

19

rs2250066

56220931

A

G

0.15

2.07 (1.45; 2.97)

7.31E-05

2.35 (1.01; 5.44)

4.40E-02

2.11 (1.52; 2.94)

9.38E-06

0.79

0

KLK11

KLK10

KLK12

  1. A2 = major allele, MAF = minor allele frequency, SCALE = Scandinavian lymphoma etiology study, UCSF = University of California, San Francisco, NA = not applicable.
  2. AEstimated with Hazard ratio, HR, and 95% confidence interval, CI, adjusting for age at diagnosis and three principal components.
  3. BMAF calculated in SCALE.
  4. Results are sorted by random effects p-value. The minor allele (A1) was investigated for association.