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Table 5 Sex-specific effects for the genetic polymorphisms in FOXO1 and SIRT1 genes, fully adjusted model

From: Genetic polymorphisms at SIRT1 and FOXO1 are associated with carotid atherosclerosis in the SAPHIR cohort

 

CCA IMT (n = 1689)

ICA IMT (n = 1687)

B score carotis (n = 1759)

SNP

β (se) men

β (se) women

p-value interaction

β (se) men

β (se) women

p-value interaction

β (se) men

β (se) women

p-value interaction

FOXO1

         

rs17446593

-0.00139 (0.00062)

0.00114 (0.00091)

0.0147

-0.00005 (0.00068)

0.00149 (0.00097)

0.2658

-0.01506 (0.02505)

0.04379 (0.03610)

0.2623

rs2721068

-0.00125 (0.00055)

-0.00093 (0.00076)

0.4421

-0.00077 (0.00060)

-0.00035 (0.00081)

0.5616

-0.01602 (0.02580)

-0.00667 (0.03023)

0.7809

rs17446614

-0.00164 (0.00063)

-0.00057 (0.00094)

0.2277

-0.00052 (0.00070)

0.00017 (0.00100)

0.5361

-0.01602 (0.02580)

0.00762 (0.03688)

0.7200

rs10507486

-0.00218 (0.00057)

-0.00138 (0.00082)

0.3032

-0.00098 (0.00063)

-0.00058 (0.00088)

0.7306

-0.04115 (0.02326)

-0.01506 (0.03266)

0.6520

rs2297627

-0.00151 (0.00051)

-0.00187 (0.00071)

0.9872

-0.00105 (0.00056)

-0.00120 (0.00076)

0.9945

-0.03709 (0.02058)

-0.03876 (0.02833)

0.9046

SIRT1

         

rs3740051

-0.00122 (0.00094)

0.00433 (0.00152)

0.0019

-0.00104 (0.00104)

0.00458 (0.00162)

0.0024

-0.04678 (0.03822)

0.133248 (0.060434)

0.0069

rs2236319

-0.00133 (0.00094)

0.00408 (0.00152)

0.0025

-0.00108 (0.00103)

0.00372 (0.00162)

0.0083

-0.04248 (0.03819)

0.1120283 (0.0606840)

0.0147

rs12413112

0.00140 (0.00073)

0.00309 (0.00106)

0.2166

0.00129 (0.00080)

0.00066 (0.00113)

0.7856

0.02879 (0.02938)

0.0809768 (0.0421386)

0.3940

rs10823108

-0.00113 (0.00092)

0.00383 (0.00153)

0.0063

-0.00118 (0.00101)

0.00359 (0.00164)

0.0101

-0.04684 (0.03751)

0.104012 (0.061163)

0.0206

rs2273773

-0.00107 (0.00093)

0.00426 (0.00153)

0.0030

-0.00097 (0.00102)

0.00378 (0.00163)

0.0091

-0.04149 (0.03782)

0.11381 (0.06106)

0.0152

rs1467568

-0.00027 (0.00050)

0.00160 (0.00070)

0.0329

-0.00021 (0.00056)

0.00215 (0.00075)

0.0124

-0.00931 (0.02029)

0.110641 (0.027819)

0.0007

  1. β-estimate and se: based on original scale of phenotype variables; p-value: p-value from the SNP*gender interaction term of the full-adjusted model, based on log-transformed phenotype variables.
  2. Full-adjusted model: age, sex, BMI, total cholesterol, HDL-cholesterol, current smoking status, hypertension, hsCRP.
  3. In bold: Significant p-values after correction for multiple testing.
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BMC Medical Genetics

ISSN: 1471-2350

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