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Table 4 Results of linear regression model for additive haplotype effects (the most common haplotype has been defined as the reference haplotype)

From: Genetic polymorphisms at SIRT1 and FOXO1 are associated with carotid atherosclerosis in the SAPHIR cohort

 

Mean common carotid IMT

Mean internal carotid IMT

Mean B-score

Haplotype

Age-and sex-adjusted

Age-and sex-adjusted

Age-and sex-adjusted

 

β (se)

p-value

β (se)

p-value

β (se)

p-value

FOXO1

      

2

-0.00011 (0.00061)

0.0777

-0.00003 (0.00066)

0.8915

-0.00724 (0.02420)

0.8421

3

-0.00040 (0.00068)

0.4764

-0.00066 (0.00074)

0.3924

-0.01994 (0.02748)

0.5289

4

-0.00326 (0.00089)

0.0006

-0.00250 (0.00096)

0.0185

-0.09123 (0.03574)

0.0077

5

0.00119 (0.00106)

0.2412

0.00164 (0.00114)

0.1446

0.00922 (0.04323)

0.6623

6

-0.00231 (0.00147)

0.0981

-0.00269 (0.00159)

0.0816

-0.06319 (0.05776)

0.2777

SIRT1

      

2

-0.00067 (0.00056)

0.2232

0.00040 (0.00060)

0.6033

0.02765 (0.02199)

0.2618

3

0.00163 (0.00063)

0.0363

0.00102 (0.00068)

0.1593

0.05442 (0.02509)

0.0765

4

0.00022 (0.00087)

0.8573

0.00026 (0.00094)

0.9468

-0.00035 (0.03497)

0.8911

  1. β-estimate and se: based on original scale of phenotype variables; p-value: based on log-transformed phenotype variables.
  2. All models are age-and sex-adjusted.
  3. In bold: Significant p-values after correction for multiple testing.
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BMC Medical Genetics

ISSN: 1471-2350

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