Table 1 Details of the genes and studies in this meta-analysis study

CCR5 (Chemokine Receptor 5)

rs7637813

Pettigrew et al, [16]

1

Irish

EDN^b

1

1.173(0.932-1.478)

10577983

Pettigrew et al, [16]

1

1.163(0.935-1.447)

rs2227010

Pettigrew et al, [16]

1

1.0(0.805-1.248)

rs17765882

Pettigrew et al, [16]

1

1.501(0.980-2.298)

rs2734648

Tregouet et al, [17]

3

Danish

EDN

1

0.969(0.788-1.191)

Tregouet et al, [17]

Finnish

EDN

1

1.186(0.947-1.486)

Tregouet et al, [17]

French

EDN

1

1.082(0.853-1.373)

Del 32/rs333

Ahluwalia et al, [18]

4

North Indian

EDN

2

2.58 (1.98–3.37)

Ahluwalia et al, [18]

South Indian

EDN

2

0.88 (0.51–1.5)

Pettigrew et al, [16]

Irish

EDN

1

1.242(0.859-1.794)

Mlynarski et al, [19]

American

ADN^c

1

0.959(0 .652 1.410)

59029 G.A/rs1799987

Pettigrew et al, [16]

10

Irish

EDN

1

1.017(0.818-1.263)

Ahluwalia et al, [18]

North Indian

EDN

2

2.22 (1.71–2.87)

Ahluwalia et al, [18]

South Indian

EDN

2

2.17 (1.43–3.29)

Buraczynska et al, [20]

Polish

EDN

2

1.83(1.43-2.34)

Mlynarski et al, [19]

American

ADN

1

0.904(0.664- 1.23)

Nakajima et al, [21]

Japanese

EDN

2

1.179(0.855-1.627)

Tregouet et al, [17]

Danish

EDN

1

1.112(0.918-1.348)

Tregouet et al, [17]

Finnish

EDN

1

1.152(0.938-1.415)

Tregouet et al, [17]

French

EDN

1

1.063(0.845-1.336)

Prasad et al, [22]

Indian

ADN

2

1.379(1.047-1.818)

ADIPOQ (Adiponectin, C1Q And Collagen Domain Containing)

rs266729

Zhang et al, [23]

2

European

EDN + ADN

1

1.120(0.929-1.35)

Wu et al, [24]

Taiwanese

EDN

2

1.39(1.0-1.9)

rs17300539

Vionnet et al, [25]

4

Danish

EDN and Ret^d

1

1.348(0.965-1.884)

Vionnet et al, [25]

Finnish

EDN and Ret

1

1(0.570-1.754)

Vionnet et al, [25]

French

EDN and Ret

1

1.472(0.998-2.171)

Prior et al, [26]

British

EDN and Ret

1

1.924 (1.024-3.617)

IL8 (Interleukin-8)

rs4073

Ahluwalia et al, [18]

2

North Indian

EDN

2

1.44 (1.1–1.88)

Ahluwalia et al, [18]

South Indian

EDN

2

1.5 (0.96–2.33)

CCL2 (Chemokine ligand 2)

rs1024611

Ahluwalia et al, [18]

2

North Indian

EDN

2

1.04 (0.8–1.36)

Joo et al, [27]

Korean

ADN

2

0.91(0.65-1.2)

rs3917887

Ahluwalia et al, [18]

2

North Indian

EDN

2

2.03 (1.57–2.63)

Ahluwalia et al, [18]

South Indian

EDN

2

1.7 (1.12–2.57)

MMP9 (Matrix Metallopeptidase 9)

rs17576

Ahluwalia et al, [18]

2

North Indian

EDN

2

1.81 (1.40–2.34)

Ahluwalia et al, [18]

South Indian

EDN

2

2.19 (2.45–3.31)

IL-10 (Interleukin-10)

–592C/A/rs1800872

Arababadi et al, [28]

2

Iranian

EDN

2

1.484(0.944-2.331)

Ezzidi et al, [2]/ Mtiraoui et al, [29]

Tunisian

EDN

2

0.915(0.751-1.114)

–819C/T/rs1800871

Ezzidi et al, [2]/ Mtiraoui et al, [29]

1

0.777(0.631-0.958)

–1082G/A/rs1800896

Ezzidi et al, [2]/ Mtiraoui et al, [29]

1

0.841(0.694-1.018)

IL-1 (Interleukin-1)

IL1A

Loughrey et al, [30]

1

Caucasian

EDN

1

0.66 (0.42-1.04)

IL1B

Loughrey et al, [30]

1

1.971(1.221-3.182)

IL1RI

Loughrey et al, [30]

1

0.94(0.618-1.429)

VEGFA (Vascular endothelial growth factor A)

- 2549 I/D/rs35569394

Yang et al, [31]

2

British

EDN and Ret

1

1.619(1.038-2.525)

Buraczynska et al, [32]

Polish

EDN

2

1.09(0.77-1.54)

+405/rs2010963

Buraczynska et al, [32]

2

Polish

EDN

2

0.949(0.658-1.369)

McKnight et al, [33]

Irish

EDN and Ret

1

0.88 (0.69-1.12)

-1499C > T/rs833061

McKnight et al, [33]

2

Irish

EDN and Ret

1

2.08(1.63-2.66)

-2578C > A/rs699947

McKnight et al, [33]

2

Irish

EDN and Ret

1

0.92(0.72-1.17)

rs2146323

Tregouet et al, [17]

3

Danish

EDN

1

0.899(0.732-1.105)

Tregouet et al, [17]

Finnish

EDN

1

0.914(0.739-1.131)

Tregouet et al, [17]

French

EDN

1

0.854(0.667-1.095)

rs3024997

Tregouet et al, [17]

3

Danish

EDN

1

0.967(0.786-1.191)

Tregouet et al, [17]

Finnish

EDN

1

0.986(0.773-1.257)

Tregouet et al, [17]

French

EDN

1

1.124(0.879-1.438)

rs3025000

Tregouet et al, [17]

3

Danish

EDN

1

0.962(0.781-1.186)

Tregouet et al, [17]

Finnish

EDN

1

0.974(0.765-1.240)

Tregouet et al, [17]

French

EDN

1

1.087(0.843-1.402)

936C/T/rs3025039

Kim et al, [34]

2

korean

EDN + ADN

2

1.632(0.984-2.708)

VEGFB (Vascular endothelial growth factor B)

rs12366035

Tregouet et al, [17]

3

Danish

EDN

1

0.784(0.633-0.971)

Tregouet et al, [17]

Finnish

EDN

1

0.92(0.727-1.163)

Tregouet et al, [17]

French

EDN

1

1.144(0.887-1.474)

VEGFC (Vascular endothelial growth factor C)

rs585706

Tregouet et al, [17]

3

Danish

EDN

1

0.8(0.562-1.139)

Tregouet et al, [17]

Finnish

EDN

1

1.318(0.917-1.895)

Tregouet et al, [17]

French

EDN

1

1.271(0.882-1.832)

IL-6 (Interleukin-6)

rs2069827

Ng et al, [35]

1

Caucasian

EDN + ADN

2

0.65(0.365-1.159)

rs1800796

Ng et al, [35]

0.935(0.588-1.487)

rs1800795

Ng et al, [35]

0.829(0.623-1.104)

rs2069837

Ng et al, [35]

0.865(0.54-1.384)

rs2069840

Ng et al, [35]

0.916(0.686-1.225)

rs2069861

Ng et al, [35]

1.505(0.882-2.569)

TGF-B1 (Transforming growth factor beta 1)

rs1800470

Jahromi et al, [36]

8

Caucasian

EDN

1

1.06(0.64-1.7)

Ahluwalia et al, [18]

North Indian

EDN

2

1.1 (0.83–1.44)

Ng et al, [37]

Caucasian

EDN + ADN

1

0.923(0.722–1.180)

McKnight et al, [33]

Irish

EDN

1

1.2(0.7-2.1)

Tregouet et al, [17]

Danish

EDN

1

0.979(0.799-1.199)

Tregouet et al, [17]

Finnish

EDN

1

1.068(0.852-1.338)

Tregouet et al, [17]

French

EDN

1

1.034(0.816-1.311)

Salgado et al, [38]

Mexican

EDN + ADN

2

1.30(0.99-1.71)

Tyr81His/rs111033611

Ahluwalia et al, [18]

1

North Indian

EDN

2

1.14 (0.53–2.46)

915 G > C/rs1800471

Ng et al, [37]

3

Caucasian

EDN + ADN

2

1.022(0.627–1.665)

McKnight et al, [33]

Irish

EDN

1

1.0(0.66-1.5)

Salgado et al, [38]

Mexican

EDN + ADN

2

4.17(1.40-12.3)

-800 A > Grs1800468

Ng et al, [37]

4

Caucasian

EDN + ADN

2

1.178(0.762–1.821)

McKnight et al, [33]

Irish

EDN

1

0.75(0.45-1.2)

Prasad et al, [22]

Indian

ADN

2

1.04(0.816-1.325)

Salgado et al, [38]

Mexican

EDN + ADN

2

0.98(0.46-2.09)

rs1800469

Ng et al, [37]

3

Caucasian

EDN + ADN

2

1.088(0.841–1.407)

McKnight et al, [33]

Irish

EDN

1

0.94(0.58-1.5)

Prasad et al, [22]

Indian

ADN

2

0.738(0.50-1.091)

rs1800472

Ng et al, [37]

1

Caucasian

EDN + ADN

2

1.168(0.639–2.135)

rs2241717

Tregouet et al, [17]

3

Danish

EDN

1

0.957(0.787-1.164)

Tregouet et al, [17]

Finnish

EDN

1

1.068(0.864-1.322)

Tregouet et al, [17]

French

EDN

1

0.917(0.729-1.155)

rs8179181

Tregouet et al, [17]

3

Danish

EDN

1

1.193(0.957-1.488)

Tregouet et al, [17]

Finnish

EDN

1

1.022(0.799-1.308)

Tregouet et al, [17]

French

EDN

1

0.944(0.722-1.234)

TGF-BR1 (TGF beta receptor 1)

rs1571589

Tregouet et al, [17]

3

Danish

EDN

1

0.951(0.746-1.213)

Tregouet et al, [17]

Finnish

EDN

1

1.111(0.836-1.476)

Tregouet et al, [17]

French

EDN

1

1.018(0.766-1.352)

rs928180

Tregouet et al, [17]

3

Danish

EDN

1

1.362(0.988-1.877)

Tregouet et al, [17]

Finnish

EDN

1

0.92(0.67-1.263)

Tregouet et al, [17]

French

EDN

1

0.901(0.608-1.334)

TGF-BR2 (TGF beta receptor 2)

747C > G/rs11466531

McKnight et al, [33]

1

Irish

EDN

1

1.37(1.0-1.89)

1149G > A/ss50394788

McKnight et al, [33]

1

Irish

EDN

1

2.432(0.81-7.303)

CCR2 (chemokine receptor type 2)

G46295A/rs1799864

Joo et al, [27]

korean

ADN

2

0.91(0.65-1.2)

rs1799865

Prasad et al, [22]

1

Indian

ADN

2

1.551(0.901-2.671)

RANTES/CCL5 (Chemokine ligand 5)

C-28G/rs2280788

Joo et al, [27]

2

korean

ADN

2

0.97(0.65-1.4)

Nakajima et al, [21]

Japanese

EDN

2

1.532(1.004-2.338)

ss161639200

Pettigrew et al, [16]

1

irish

EDN

1

1.140(0.821-1.584)

rs9898132

Pettigrew et al, [16]

1

Irish

EDN

1

1.092(0.746-1.599)

G-403A/rs2107538

Joo et al, [27]

3

Korean

ADN

2

0.8(0.59-1.0)

Pettigrew et al, [16]

Irish

EDN

1

1.085(0.81-1.452)

Nakajima et al, [21]

Japanese

EDN

2

0.88(0.632-1.225)

EPO (Erythropoietin)

rs1617640

Tong et al, [39]

3

American

EDN + ADN

2

1.446(1.145-1.826)

Tong et al, [39]

1

1.535(1.320-1.787)

Tong et al, [39]

1

1.382(1.050-1.820)

TNFα (Tumor necrosis factor)

-308/rs1800629

Prasad et al, [22]

1

Indian

ADN

2

1.383(0.775-2.468)