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Table 1 Details of the genes and studies in this meta-analysis study

From: Meta-analysis of diabetic nephropathy associated genetic variants in inflammation and angiogenesis involved in different biochemical pathways

Gene SNP Article No. of studies Population Case definition T1D/T2D ORa
CCR5 (Chemokine Receptor 5) rs7637813 Pettigrew et al, [16] 1 Irish EDNb 1 1.173(0.932-1.478)
  10577983 Pettigrew et al, [16] 1     1.163(0.935-1.447)
  rs2227010 Pettigrew et al, [16] 1     1.0(0.805-1.248)
  rs17765882 Pettigrew et al, [16] 1     1.501(0.980-2.298)
  rs2734648 Tregouet et al, [17] 3 Danish EDN 1 0.969(0.788-1.191)
   Tregouet et al, [17]   Finnish EDN 1 1.186(0.947-1.486)
   Tregouet et al, [17]   French EDN 1 1.082(0.853-1.373)
  Del 32/rs333 Ahluwalia et al, [18] 4 North Indian EDN 2 2.58 (1.98–3.37)
   Ahluwalia et al, [18]   South Indian EDN 2 0.88 (0.51–1.5)
   Pettigrew et al, [16]   Irish EDN 1 1.242(0.859-1.794)
   Mlynarski et al, [19]   American ADNc 1 0.959(0 .652 1.410)
  59029 G.A/rs1799987 Pettigrew et al, [16] 10 Irish EDN 1 1.017(0.818-1.263)
   Ahluwalia et al, [18]   North Indian EDN 2 2.22 (1.71–2.87)
   Ahluwalia et al, [18]   South Indian EDN 2 2.17 (1.43–3.29)
   Buraczynska et al, [20]   Polish EDN 2 1.83(1.43-2.34)
   Mlynarski et al, [19]   American ADN 1 0.904(0.664- 1.23)
   Nakajima et al, [21]   Japanese EDN 2 1.179(0.855-1.627)
   Tregouet et al, [17]   Danish EDN 1 1.112(0.918-1.348)
   Tregouet et al, [17]   Finnish EDN 1 1.152(0.938-1.415)
   Tregouet et al, [17]   French EDN 1 1.063(0.845-1.336)
   Prasad et al, [22]   Indian ADN 2 1.379(1.047-1.818)
ADIPOQ (Adiponectin, C1Q And Collagen Domain Containing) rs266729 Zhang et al, [23] 2 European EDN + ADN 1 1.120(0.929-1.35)
   Wu et al, [24]   Taiwanese EDN 2 1.39(1.0-1.9)
  rs17300539 Vionnet et al, [25] 4 Danish EDN and Retd 1 1.348(0.965-1.884)
   Vionnet et al, [25]   Finnish EDN and Ret 1 1(0.570-1.754)
   Vionnet et al, [25]   French EDN and Ret 1 1.472(0.998-2.171)
   Prior et al, [26]   British EDN and Ret 1 1.924 (1.024-3.617)
IL8 (Interleukin-8) rs4073 Ahluwalia et al, [18] 2 North Indian EDN 2 1.44 (1.1–1.88)
   Ahluwalia et al, [18]   South Indian EDN 2 1.5 (0.96–2.33)
CCL2 (Chemokine ligand 2) rs1024611 Ahluwalia et al, [18] 2 North Indian EDN 2 1.04 (0.8–1.36)
   Joo et al, [27]   Korean ADN 2 0.91(0.65-1.2)
  rs3917887 Ahluwalia et al, [18] 2 North Indian EDN 2 2.03 (1.57–2.63)
   Ahluwalia et al, [18]   South Indian EDN 2 1.7 (1.12–2.57)
MMP9 (Matrix Metallopeptidase 9) rs17576 Ahluwalia et al, [18] 2 North Indian EDN 2 1.81 (1.40–2.34)
   Ahluwalia et al, [18]   South Indian EDN 2 2.19 (2.45–3.31)
IL-10 (Interleukin-10) –592C/A/rs1800872 Arababadi et al, [28] 2 Iranian EDN 2 1.484(0.944-2.331)
   Ezzidi et al, [2]/ Mtiraoui et al, [29]   Tunisian EDN 2 0.915(0.751-1.114)
  –819C/T/rs1800871 Ezzidi et al, [2]/ Mtiraoui et al, [29] 1     0.777(0.631-0.958)
  –1082G/A/rs1800896 Ezzidi et al, [2]/ Mtiraoui et al, [29] 1     0.841(0.694-1.018)
IL-1 (Interleukin-1) IL1A Loughrey et al, [30] 1 Caucasian EDN 1 0.66 (0.42-1.04)
  IL1B Loughrey et al, [30] 1     1.971(1.221-3.182)
  IL1RI Loughrey et al, [30] 1     0.94(0.618-1.429)
VEGFA (Vascular endothelial growth factor A) - 2549 I/D/rs35569394 Yang et al, [31] 2 British EDN and Ret 1 1.619(1.038-2.525)
   Buraczynska et al, [32]   Polish EDN 2 1.09(0.77-1.54)
  +405/rs2010963 Buraczynska et al, [32] 2 Polish EDN 2 0.949(0.658-1.369)
   McKnight et al, [33]   Irish EDN and Ret 1 0.88 (0.69-1.12)
  -1499C > T/rs833061 McKnight et al, [33] 2 Irish EDN and Ret 1 2.08(1.63-2.66)
  -2578C > A/rs699947 McKnight et al, [33] 2 Irish EDN and Ret 1 0.92(0.72-1.17)
  rs2146323 Tregouet et al, [17] 3 Danish EDN 1 0.899(0.732-1.105)
   Tregouet et al, [17]   Finnish EDN 1 0.914(0.739-1.131)
   Tregouet et al, [17]   French EDN 1 0.854(0.667-1.095)
  rs3024997 Tregouet et al, [17] 3 Danish EDN 1 0.967(0.786-1.191)
   Tregouet et al, [17]   Finnish EDN 1 0.986(0.773-1.257)
   Tregouet et al, [17]   French EDN 1 1.124(0.879-1.438)
  rs3025000 Tregouet et al, [17] 3 Danish EDN 1 0.962(0.781-1.186)
   Tregouet et al, [17]   Finnish EDN 1 0.974(0.765-1.240)
   Tregouet et al, [17]   French EDN 1 1.087(0.843-1.402)
  936C/T/rs3025039 Kim et al, [34] 2 korean EDN + ADN 2 1.632(0.984-2.708)
VEGFB (Vascular endothelial growth factor B) rs12366035 Tregouet et al, [17] 3 Danish EDN 1 0.784(0.633-0.971)
   Tregouet et al, [17]   Finnish EDN 1 0.92(0.727-1.163)
   Tregouet et al, [17]   French EDN 1 1.144(0.887-1.474)
VEGFC (Vascular endothelial growth factor C) rs585706 Tregouet et al, [17] 3 Danish EDN 1 0.8(0.562-1.139)
   Tregouet et al, [17]   Finnish EDN 1 1.318(0.917-1.895)
   Tregouet et al, [17]   French EDN 1 1.271(0.882-1.832)
IL-6 (Interleukin-6) rs2069827 Ng et al, [35] 1 Caucasian EDN + ADN 2 0.65(0.365-1.159)
  rs1800796 Ng et al, [35]      0.935(0.588-1.487)
  rs1800795 Ng et al, [35]      0.829(0.623-1.104)
  rs2069837 Ng et al, [35]      0.865(0.54-1.384)
  rs2069840 Ng et al, [35]      0.916(0.686-1.225)
  rs2069861 Ng et al, [35]      1.505(0.882-2.569)
TGF-B1 (Transforming growth factor beta 1) rs1800470 Jahromi et al, [36] 8 Caucasian EDN 1 1.06(0.64-1.7)
   Ahluwalia et al, [18]   North Indian EDN 2 1.1 (0.83–1.44)
   Ng et al, [37]   Caucasian EDN + ADN 1 0.923(0.722–1.180)
   McKnight et al, [33]   Irish EDN 1 1.2(0.7-2.1)
   Tregouet et al, [17]   Danish EDN 1 0.979(0.799-1.199)
   Tregouet et al, [17]   Finnish EDN 1 1.068(0.852-1.338)
   Tregouet et al, [17]   French EDN 1 1.034(0.816-1.311)
   Salgado et al, [38]   Mexican EDN + ADN 2 1.30(0.99-1.71)
  Tyr81His/rs111033611 Ahluwalia et al, [18] 1 North Indian EDN 2 1.14 (0.53–2.46)
  915 G > C/rs1800471 Ng et al, [37] 3 Caucasian EDN + ADN 2 1.022(0.627–1.665)
   McKnight et al, [33]   Irish EDN 1 1.0(0.66-1.5)
   Salgado et al, [38]   Mexican EDN + ADN 2 4.17(1.40-12.3)
  -800 A > Grs1800468 Ng et al, [37] 4 Caucasian EDN + ADN 2 1.178(0.762–1.821)
   McKnight et al, [33]   Irish EDN 1 0.75(0.45-1.2)
   Prasad et al, [22]   Indian ADN 2 1.04(0.816-1.325)
   Salgado et al, [38]   Mexican EDN + ADN 2 0.98(0.46-2.09)
  rs1800469 Ng et al, [37] 3 Caucasian EDN + ADN 2 1.088(0.841–1.407)
   McKnight et al, [33]   Irish EDN 1 0.94(0.58-1.5)
   Prasad et al, [22]   Indian ADN 2 0.738(0.50-1.091)
  rs1800472 Ng et al, [37] 1 Caucasian EDN + ADN 2 1.168(0.639–2.135)
  rs2241717 Tregouet et al, [17] 3 Danish EDN 1 0.957(0.787-1.164)
   Tregouet et al, [17]   Finnish EDN 1 1.068(0.864-1.322)
   Tregouet et al, [17]   French EDN 1 0.917(0.729-1.155)
  rs8179181 Tregouet et al, [17] 3 Danish EDN 1 1.193(0.957-1.488)
   Tregouet et al, [17]   Finnish EDN 1 1.022(0.799-1.308)
   Tregouet et al, [17]   French EDN 1 0.944(0.722-1.234)
TGF-BR1 (TGF beta receptor 1) rs1571589 Tregouet et al, [17] 3 Danish EDN 1 0.951(0.746-1.213)
   Tregouet et al, [17]   Finnish EDN 1 1.111(0.836-1.476)
   Tregouet et al, [17]   French EDN 1 1.018(0.766-1.352)
  rs928180 Tregouet et al, [17] 3 Danish EDN 1 1.362(0.988-1.877)
   Tregouet et al, [17]   Finnish EDN 1 0.92(0.67-1.263)
   Tregouet et al, [17]   French EDN 1 0.901(0.608-1.334)
TGF-BR2 (TGF beta receptor 2) 747C > G/rs11466531 McKnight et al, [33] 1 Irish EDN 1 1.37(1.0-1.89)
  1149G > A/ss50394788 McKnight et al, [33] 1 Irish EDN 1 2.432(0.81-7.303)
CCR2 (chemokine receptor type 2) G46295A/rs1799864 Joo et al, [27]   korean ADN 2 0.91(0.65-1.2)
  rs1799865 Prasad et al, [22] 1 Indian ADN 2 1.551(0.901-2.671)
RANTES/CCL5 (Chemokine ligand 5) C-28G/rs2280788 Joo et al, [27] 2 korean ADN 2 0.97(0.65-1.4)
   Nakajima et al, [21]   Japanese EDN 2 1.532(1.004-2.338)
  ss161639200 Pettigrew et al, [16] 1 irish EDN 1 1.140(0.821-1.584)
  rs9898132 Pettigrew et al, [16] 1 Irish EDN 1 1.092(0.746-1.599)
  G-403A/rs2107538 Joo et al, [27] 3 Korean ADN 2 0.8(0.59-1.0)
   Pettigrew et al, [16]   Irish EDN 1 1.085(0.81-1.452)
   Nakajima et al, [21]   Japanese EDN 2 0.88(0.632-1.225)
EPO (Erythropoietin) rs1617640 Tong et al, [39] 3 American EDN + ADN 2 1.446(1.145-1.826)
   Tong et al, [39]     1 1.535(1.320-1.787)
   Tong et al, [39]     1 1.382(1.050-1.820)
TNFα (Tumor necrosis factor) -308/rs1800629 Prasad et al, [22] 1 Indian ADN 2 1.383(0.775-2.468)
  1. aOR, Odds ratio (95% CI); bEDN, established diabetic nephropathy; cADN, advanced diabetic nephropathy; dRet, retinopathy.
  2. This meta- analysis included 55 SNPs in 18 genes of inflammatory cytokines and angiogenesis which were associated with diabetic nephropathy.