Table 2 Family-based replication analyses in the combined United Kingdom NTD cohort
From: Replication and exploratory analysis of 24 candidate risk polymorphisms for neural tube defects
Gene SNP | Test/Model* | Result in Irish NTD Cohort [[45]] | Result in UK Cohort |
|---|---|---|---|
GRR [95% CI], p-value | GRR [95% CI], p-value | ||
ADA rs452159 | LL Case Dom | 2.28 [1.29-4.05], p = 0.0047 | 1.86 [1.01-3.40], p = 0.045 |
CDKN2A rs3218009 | LL Mat Dom | 2.32 [1.45-3.71], p = 0.0004 | 1.16 [0.81-1.65], p = 0.418 |
COMT rs174675 | LL Case Dom | 0.41 [0.23-0.73], p = 0.0028 | 0.89 [0.55-1.43], p = 0.621 |
CUBN rs11254375 | LL Mat Dom | 1.48 [1.10-1.99], p = 0.0097 | 1.22 [0.89-1.66], p = 0.210 |
DNMT3A rs7560488 | LL Case Rec | 2.10 [1.31-3.38], p = 0.0021 | 0.89 [0.61-1.28], p = 0.520 |
DNMT3B rs6058896 | TDT | 1.88 [1.24-2.85], p = 0.0029 | 1.18 [0.77-1.82], p = 0.443 |
FOLH1 rs16906205** | LL Mat Dom | 0.43 [0.23-0.78], p = 0.0060 | 1.10 [0.75-1.63], p = 0.619 |
GART rs2070388 | TDT | 0.53 [0.36-0.78], p = 0.0012 | 0.73 [0.52-1.03], p = 0.070 |
GNMT rs9462856 | LL Case Dom | 0.55 [0.36-0.83], p = 0.0048 | 1.19 [0.85-1.68], p = 0.308 |
MAT2B rs17535909 | LL Case Rec | 1.69 [1.18-2.42], p = 0.0045 | Failed genotyping |
MTHFD1 rs11627525 | LL Mat Rec | 2.17 [1.24-3.79], p = 0.0067 | 1.13 [0.76-1.68], p = 0.545 |
MTHFD1 rs2236225 | LL Case Dom | 1.66 [1.16-2.37], p = 0.0054 | 1.21 [0.84-1.74], p = 0.299 |
MTR rs10925260 | LL Case Rec | 0.64 [0.48-0.86], p = 0.0031 | 0.71 [0.53-0.94], p = 0.019 |
PEMT rs4646402 | LL Case Dom | 0.600 [0.46-0.8], p = 0.0005 | 0.92 [0.70-1.23], p = 0.585 |
PEMT rs16961845 | LL Mat Rec | 1.92 [1.18-3.11], p = 0.0082 | 0.73 [0.46-1.15], p = 0.171 |