Figure 1
From: Apparently synonymous substitutions in FGFR2affect splicing and result in mild Crouzon syndrome
Pedigrees and facial features of individuals with FGFR2 mutations. A, Pedigree of Family 1; solid symbols represent clinically confirmed craniosynostosis and hatched symbols represent individuals with a similar crouzonoid appearance but without confirmed craniosynostosis. *confirmed heterozygosity for c.1083A>G. B, Facial appearance of II-1 from Family 1 aged 33 years. C, Abbreviated pedigree of Family 2; notation of symbols as in part A.†confirmed heterozygosity for c.1083A>T. D, Facial appearance of III-1 from Family 2 aged 8.75 years (left) and 43 years (right).