Association study of two inflammation-related polymorphisms with susceptibility to hepatocellular carcinoma: a meta-analysis

Table 6 Subgroup-analysis of the miR-499 rs3746444 polymorphisms and HCC risk

Subgroup	Comparisons	Test of association			Test of heterogeneity
Subgroup	Comparisons	OR	95% CI	P value	Model	I²	P value
C versus T
Population		OR	95% CI	P value	Model	I²	P value
Chinese	2	1.424	0.730-2.776	0.300	R	83.3%	0.015
Other	2	0.949	0.764-1.179	0.636	F	69.9%	0.068
Sample size
<300	1	2.020	1.333-3.063	0.001	NA	NA	NA
>300	3	0.968	0.804-1.165	0.733	F	41.8%	0.179
CC versus TT
Population		OR	95% CI	P value	Model	I²	P value
Chinese	2	2.171	1.149-4.104	0.017	F	73.4%	0.053
Other	2	1.021	0.638-1.634	0.931	F	29.0%	0.235
Sample size
<300	1	3.600	1.539-8.421	0.003	NA	NA	NA
>300	3	0.998	0.647-1.541	0.994	F	41.8%	0.179
CC/CT versus TT
Population		OR	95% CI	P value	Model	I²	P value
Chinese	2	1.325	0.962-1.824	0.085	F	73.1%	0.054
Other	2	0.838	0.611-1.148	0.271	F	46.2%	0.173
Sample size
<300	1	2.087	1.184-3.679	0.011	NA	NA	NA
>300	3	0.916	0.716-1.174	0.489	F	24.8%	0.264

ISSN: 1471-2350