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Table 2 SNP-by-DBP interactions on CAC quantity*

From: The relationship between diastolic blood pressure and coronary artery calcification is dependent on single nucleotide polymorphisms on chromosome 9p21.3

SNP Closest reference gene Coded allele GENOA CAF FHS CAF GENOA interaction P FHS Interaction P Combined P Bonferroni-corrected combined P§
rs2069416 CDKN2B-AS1 A 0.3666 0.3351 0.047 0.033 6.50 × 10-3 0.0455
rs1333040 CDKN2B-AS1 C 0.5829 0.6031 0.012 0.250 0.0246 0.1722
rs1333049 (CDKN2B-AS1) C 0.5107 0.5089 0.014 0.273 0.0291 0.2037
rs1333050 (CDKN2B-AS1) C 0.6652 0.7009 0.069 0.565 0.2008 1
rs2069418 CDKN2B-AS1 C 0.5447 - 0.289 - - -
rs3218009 CDKN2B-AS1 C 0.8106 - 0.370 - - -
rs3731239 CDKN2A C 0.3766 - 0.711 - - -
  1. SNP = single nucleotide polymorphism; DBP = diastolic blood pressure; CAF = coded allele frequency; GENOA = Genetic Epidemiology Network of Arteriopathy; FHS = Framingham Heart Study Offspring cohort.
  2. *Adjusted for age, sex, systolic blood pressure, anti-hypertensive medication use, diabetes status, fasting glucose levels, ln(pack years + 1), LDL:HDL ratio, and statin drug use.
  3. †Intergenic SNPs are represented in parentheses naming the nearest gene, e.g. (CDKN2B-AS1).
  4. Combined P was achieved through Stouffer’s z-test, which considers both p-values and sample sizes.
  5. §Bonferroni-corrected for testing 7 SNPs.