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Table 2 SNP-by-DBP interactions on CAC quantity*

From: The relationship between diastolic blood pressure and coronary artery calcification is dependent on single nucleotide polymorphisms on chromosome 9p21.3

SNP

Closest reference gene†

Coded allele

GENOA CAF

FHS CAF

GENOA interaction P

FHS Interaction P

Combined P‡

Bonferroni-corrected combined P§

rs2069416

CDKN2B-AS1

A

0.3666

0.3351

0.047

0.033

6.50 × 10-3

0.0455

rs1333040

CDKN2B-AS1

C

0.5829

0.6031

0.012

0.250

0.0246

0.1722

rs1333049

(CDKN2B-AS1)

C

0.5107

0.5089

0.014

0.273

0.0291

0.2037

rs1333050

(CDKN2B-AS1)

C

0.6652

0.7009

0.069

0.565

0.2008

1

rs2069418

CDKN2B-AS1

C

0.5447

-

0.289

-

-

-

rs3218009

CDKN2B-AS1

C

0.8106

-

0.370

-

-

-

rs3731239

CDKN2A

C

0.3766

-

0.711

-

-

-

  1. SNP = single nucleotide polymorphism; DBP = diastolic blood pressure; CAF = coded allele frequency; GENOA = Genetic Epidemiology Network of Arteriopathy; FHS = Framingham Heart Study Offspring cohort.
  2. *Adjusted for age, sex, systolic blood pressure, anti-hypertensive medication use, diabetes status, fasting glucose levels, ln(pack years + 1), LDL:HDL ratio, and statin drug use.
  3. †Intergenic SNPs are represented in parentheses naming the nearest gene, e.g. (CDKN2B-AS1).
  4. ‡Combined P was achieved through Stouffer’s z-test, which considers both p-values and sample sizes.
  5. §Bonferroni-corrected for testing 7 SNPs.