Figure 2

Distribution of CD8+ T-lymphocyte numbers (A) and of total body iron stores (B) in HH patients. Distribution of CD8+ T-lymphocyte numbers (A) and of total body iron stores (TBIS) (B) in all HH patients (Portuguese and Canadian), according to the combination of the conserved haplotypes (defined by SNP markers PGBD1-ZNF193-ZNF165), which divide subjects in three groups: patients homozygous for the ancestral A-A-T haplotype (n=50), patients heterozygous for the G-G-G haplotype (n=6) and homozygous for the G-G-G haplotype (n=1). Dashed lines represent: (A)-the median value of CD8+ T-cells (see Material and Methods); (B)-level of TBIS above which iron stores is considered severe. Average values are shown in red lines. Open circles represent Canadian patients.