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Table 2 Non-synonymous sequence variants within the oxygen-dependent degradation domain of the HIF1A gene with pre-eclamptic first pregnancies (N = 108) and women with normotensive pregnancies (N = 101)

From: Non-synonymous sequence variants within the oxygen-dependent degradation domain of the HIF1Agene are not associated with pre-eclampsia in the Finnish population

Variation

Amino acid

No. of alleles in cases

No. of alleles in controls

P-value*

OR (95% CI)

rs11549465 (c.1744C>T)

     

C allele

Pro582

208

189

0.26

0.56 (0.23–1.38)

T allele

Ser582

8

13

  

rs11529467 (c.1762G>A)

     

G allele

Ala588

212

199

1.00

1.25 (0.28–5.66)

A allele

Thr588

4

3

  
  1. *Fisher's exact test