Structure of the HIF-1α protein, and polymorphisms identified by sequencing the exon 12 of the HIF1A gene. bHLH = basic-helix-loop-helix domain, PAS = Per-Arnt-Sim domain, ODD = oxygen dependent degradation domain, N-TAD = N-terminal transactivation domain, C-TAD = C-terminal transactivation domain. Rs11549465 changes residue 582 of HIF-1α from proline to serine (P582S), and rs11549467 changes residue 588 of HIF-1α from alanine (A) to threonine (T). Variant rs34005929 is a synonymous change of the last nucleotide of codon 580 encoding a leucine (L). Variant changing the last nucleotide of codon 600 (T) is predicted to be a silent polymorphism.