Skip to main content

Table 2 Association of SREBP-2 gene polymorphisms between the AVN patients and controls

From: Significant association of SREBP-2genetic polymorphisms with avascular necrosis in the Korean population

Loci

Sub-group

Genotype

 

Allele 2 vs. 1

Codominant Heterozy

Dominant

Recessive

  

11

12

22

MAF

  

(11 vs 12 vs 22)*

12 + 22 vs. 11

22 vs. 11 + 12

      

OR (95% CI)

P†

OR (95% CI)

P†

OR (95% CI)

P†

OR (95% CI)

P†

IVS1+8408 T>C

 

TT

CT

CC

         

(rs2267439)

CTL

77

138

55

0.459

        
 

AVN

159

218

66

0.395

0.751

(0.604–0.935)

0.010

0.744

(0.595–0.930)

0.009

0.702

(0.504–0.978)

0.036

0.647

(0.433–0.964)

0.033

IVS3-342 G>T

 

GG

GT

TT

         

(rs2269657)

CTL

146

107

16

0.258

        
 

AVN

241

149

32

0.263

1.069

(0.835–1.369)

0.596

1.070

(0.834–1.372)

0.595

1.039

(0.762–1.415)

0.810

1.305

(0.697–2.442)

0.406

IVS11+414 G>A

 

GG

AG

AA

         

(rs1052717)

CTL

132

120

19

0.292

        
 

AVN

202

186

53

0.331

1.207

(0.954–1.525)

0.117

1.206

(0.954–1.525)

0.118

1.133

(0.835–1.539)

0.423

1.796

(1.034–3.120)

0.038

IVS12-1667 G>A

 

GG

AG

AA

         

(rs2267443)

CTL

116

121

29

0.337

        
 

AVN

169

192

69

0.384

1.265

(1.006–1.590)

0.044

1.259

(1.003–1.579)

0.047

1.254

(0.916–1.718)

0.157

1.589

(0.996–2.535)

0.052

  1. *11: homozygotes for the major allele, 12: heterozygotes and 22: homozygotes for the minor allele.
  2. † Logistic regression analyses were used for calculating. bold: P value < 0.05