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Table 4 Results of haplotype association analysis for type 2 diabetes in interaction effect models (n = 1,968).

From: Association between variations in the TLR4gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol

 

Men

Women

 

HR [95% CI]

p-value

HR [95% CI]

p-value

TC/HDL-C

1.02 [0.90; 1.15]

0.74

1.95 [1.55; 2.45]

1.2 × 10-8

H2

0.77 [0.36, 1.65]

0.5

3.11 [1.07; 9.00]

0.04

H3

1.04 [0.55; 1.96]

0.89

4.41 [1.37; 14.21]

0.01

H4

0.29 [0.08; 1.02]

0.05

4.01 [0.99; 16.17]

0.05

H5

0.11 [0.03; 0.45]

1.9 × 10-3

1.47 [0.34; 6.40]

0.61

H6

0.45 [0.11; 1.73]

0.24

0.29 [0.01; 6.73]

0.44

H7

0.05 [0.00; 0.52]

0.01

0.41 [0.02; 10.33]

0.59

TC/HDL-C × H2

1.08 [0.95; 1,24]

0.22

0.76 [0.61; 0.96]

0.02

TC/HDL-C × H3

1.01 [0.92; 1.10]

0.9

0.70 [0.54; 0.91]

0.01

TC/HDL-C × H4

1.28 [1.03; 1.58]

0.02

0.68 [0.51; 0.89]

0.01

TC/HDL-C × H5

1.51 [1.23; 1.87]

1.1 × 10-4

0.95 [0.70; 1.29]

0.74

TC/HDL-C × H6

1.14 [0.95; 1.37]

0.15

1.17 [0.65; 2.08]

0.61

TC/HDL-C × H7

1.63 [1.26; 2.12]

2.1 × 10-4

1.15 [0.64; 2.07]

0.64