'Fat mass and obesity associated' gene (FTO): No significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents

Table 3 Baseline measures of blood parameters and BMI-SDS in German fasted obese children and adolescents

Parameter	N¹	Genotype	N (%)	Mean ± SD	Additive genetic model²
					Estimate	95% CI	p-value³
BMI-SDS⁷	519	TT	140 (27)	2.53 ± 0.49	0.025	-0.034...0.083	0.410
		AT	238 (46)	2.60 ± 0.51
		AA	141 (27)	2.58 ± 0.52
TGL [mg/dl]⁴	332	TT	94 (28)	115.15 ± 65.17	-0.008	-0.039...0.022	0.590
		AT	159 (48)	107.89 ± 52.75
		AA	79 (24)	109.52 ± 53.64
LDL [mg/dl]⁵	323	TT	93 (29)	104.18 ± 30.12	-0.001	-0.021...0.020	0.947
		AT	153 (47)	106.52 ± 32.67
		AA	77 (24)	103.42 ± 30.75
HDL [mg/dl]⁶	324	TT	93 (29)	50.25 ± 11.26	-0.004	-0.018...0.010	0.601
		AT	153 (47)	50.92 ± 11.28
		AA	78 (24)	49.33 ± 11.54
Glucose [mg/dl]⁷	480	TT	136 (28)	85.54 ± 9.09	-0.003	-0.009...0.003	0.350
		AT	216 (45)	84.67 ± 9.54
		AA	128 (27)	84.37 ± 8.60

¹ total number of obese individuals, from which baseline measures were available; ² linear regression analyses for log10-transformed parameters or BMI-SDS http://www.mybmi.de including covariates age and sex; ³ two-sided p-value; ⁴ TGL: triglycerides; ⁵ LDL: low density lipoprotein; ⁶ HDL: high density lipoprotein; ⁷A trend towards a deviation from Hardy-Weinberg equilibrium was observable for genotype frequencies for BMI-SDS and glucose (exact p = 0.07; 0.03, respectively). This finding, however, is not surprising and expected in case of a true genetic association and indeed the number of homozygotes for the at-risk A-allele was increased in these patients compared to controls.

ISSN: 1471-2350