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Table 2 Analyses of BMI-SDS changes in German obese children and adolescents who participated in the obesity intervention program 'Obeldicks'

From: 'Fat mass and obesity associated' gene (FTO): No significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents

Parameter

N1

Genotype

N (%)

Mean ± SD

Additive genetic model2

     

Estimate

95% CI

p-value3

Δ BMI-SDS4,5

207

TT

53 (26)

0.33 ± 0.40

-0.032

-0.091...0.027

0.287

  

AT

86 (41)

0.25 ± 0.27

   
  

AA

68 (33)

0.27 ± 0.27

   
  1. 1 total number of individuals who participated in the obesity intervention program; 2 linear regression analyses for BMI-SDS http://www.mybmi.de including covariates age and sex- including baseline BMI-SDS did not substantially alter the result; the p-value for the sex main effect was 0.740; 3 two-sided p-value; 4 median time interval between repeated measurements 12 months; positive values for descriptive statistics indicate weight reduction in units of BMI-SDS; asymptotic two-sided p-value for Kruskal-Wallis Test 0.44; 5 A trend towards a deviation from Hardy-Weinberg equilibrium was observable for genotype frequencies for Δ BMI-SDS (exact p = 0.02). This finding, however, is not surprising and expected in case of a true genetic association and indeed the number of homozygotes for the at-risk A-allele was increased in these patients compared to controls.