| | | Genotypes N (%) | Alleles1
(%) | Odds ratio2
[95% CI] |
|---|
| | N | TT | AT | AA | T | A | TT | AT | AA |
Cases3
| 519 | 140 (27) | 238 (46) | 141 (27) | 0.50 | 0.50 | 1.00 | 1.24 | 1.54 |
Controls4
| 178 | 56 (31) | 86 (48) | 36 (20) | 0.56 | 0.44 | | [0.98...1.57] | [0.96...2.46] |
-
1 genotype and allele frequencies of control samples (normal weight adults) are similar to the allele frequencies reported for the European population in the dbSNP database http://www.ncbi.nlm.nih.gov/SNP/, 2 asymptotic one-sided p-value for association of the A-allele with obesity is p = 0.036, 3 cases comprise 519 German overweight and obese children and adolescents, 4 controls comprise 178 normal weight healthy adults
